[HTML][HTML] Validation approaches for computational drug repurposing: a review

M Pillai, D Wu - AMIA Annual Symposium Proceedings, 2023 - ncbi.nlm.nih.gov
… 628 studies using computational approaches for drug repurposing were identified in this
review, showing the vast amount of research that has been conducted in this area. However, …

[HTML][HTML] Computational drug repurposing for inflammatory bowel disease using genetic information

L Grenier, P Hu - Computational and structural biotechnology journal, 2019 - Elsevier
approaches. Our approach for drug repurposing was multi-layered; it not only focused on
the interactions between drugs and risk IBD genes, but also the interactions between …

Computational techniques for drug repurposing: a paradigm shift in drug discovery

MRP Rao, IS Ghadge, SP Kulkarni… - Current Drug …, 2023 - ingentaconnect.com
… Usually, this method is used in in silico or computational approaches. Off-target … drug
repurposing [41]. Fig. (3) [42-52] provides a brief overview of different systemic drug repurposing ap…

Drug repurposing approaches: existing leads for novel threats and drug targets

T Usha, SK Middha, AA Kukanur… - Current Protein and …, 2021 - ingentaconnect.com
… One promising strategy for translational success is drug repurposing. In Table 2, we have
listed a few drugs that have been repurposed for CNS disorders, discussed their mechanism of …

Drug repurposing using computational methods to identify therapeutic options for COVID-19

S Mahdian, A Ebrahim-Habibi, M Zarrabi - Journal of Diabetes & Metabolic …, 2020 - Springer
… In this paper, the drug repurposing strategy is applied … drug repurposing strategy was
applied using virtual screening to identify therapeutic options for COVID-19. FDA-approved drugs

Computational Approach for Drug Repurposing

F NAZ, R PARASHAR, AK JHA, NK JHA… - Computational Biology …, 2024 - books.google.com
Drug repurposing approaches are those approaches in which discovery of drugs comes from
the preexisting knowledge related to drugs… of the molecule or drug in terms of molecule type…

Drug repurposing using biological networks

FJ Somolinos, C León, S Guerrero-Aspizua - Processes, 2021 - mdpi.com
… , networks are a preferred computational approach to model interactions between molecules
… network models for drug repurposing, nodes in the networks represent drugs, diseases, or …

Computational drug repurposing to predict approved and novel drug-disease associations

Z Khalid, OU Sezerman - Journal of Molecular Graphics and Modelling, 2018 - Elsevier
Drug often binds to more than one targets defined as polypharmacology, one application of
which is drug repurposing also referred as drug … In addition to the computational approaches, …

A comprehensive review of drug repurposing strategies against known drug targets of COVID-19

A Khataniar, U Pathak, S Rajkhowa, AN Jha - Covid, 2022 - mdpi.com
… and computational drug repurposing strategies that have been utilized against significant
drug … , a gene signature database can aid drug repurposing using computational approaches. …

Exploring the possibility of drug repurposing for cancer therapy targeting human lactate dehydrogenase A: A computational approach

SK Paul, K Dutta Chowdhury, SR Dey… - Journal of …, 2023 - Taylor & Francis
… In this computational study, we have performed a pharmacophore based screening of
approved drugs followed by a molecular docking based screening to find a few potential LDHA …