[HTML][HTML] A data-driven methodology towards evaluating the potential of drug repurposing hypotheses

LP Santamaría, EU Carro, MD Uzquiano… - Computational and …, 2021 - Elsevier
… in repurposing … actual repurposing-related information and non-repurposing data. The
insights obtained could be relevant when suggesting new potential drug repurposing hypotheses. …

Drug repurposing using real-world data

GSQ Tan, EK Sloan, P Lambert, CMJ Kirkpatrick… - Drug discovery today, 2023 - Elsevier
… Findings from this review support the idea that RWD can be used in drug repurposing for
hypothesis generation, hypothesis validation and safety assessment. In conjunction with the …

Using human experience to identify drug repurposing opportunities: theory and practice

D Cavalla - British Journal of Clinical Pharmacology, 2019 - Wiley Online Library
… Although case reports are often the bases for repurposing hypotheses, they lack statistical
rigour and, for the purposes of this review, are not included in the definition of retrospective …

[HTML][HTML] Learning Drug-Disease-Target Embedding (DDTE) from knowledge graphs to inform drug repurposing hypotheses

C Moon, C Jin, X Dong, S Abrar, W Zheng… - Journal of biomedical …, 2021 - Elsevier
We aimed to develop and validate a new graph embedding algorithm for embedding drug-disease-target
networks to generate novel drug repurposing hypotheses. Our model denotes …

[HTML][HTML] The failure of drug repurposing for COVID-19 as an effect of excessive hypothesis testing and weak mechanistic evidence

M Maziarz, A Stencel - History and Philosophy of the Life Sciences, 2022 - Springer
… of drug repurposing for COVID-19 is susceptible to this problem. In unfavorable circumstances,
multiple comparisons can drastically impede true inferences. For example, Colhoun et al. …

[HTML][HTML] Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects

M Chartier, LP Morency, MI Zylber… - BMC Pharmacology and …, 2017 - Springer
drugs and 1216 unique potential cross-reactivity protein targets. We highlight a few cases
with a potential for drug repurposing (… -sites of the primary drug targets and visualise them for …

Drug repurposing (DR): an emerging approach in drug discovery

M Rudrapal, SJ Khairnar, AG Jadhav - … repurposing-hypothesis …, 2020 - books.google.com
Drug repurposing (DR)(also known as drug repositioning) is a process of identifying new …
/available drugs. It is an effective strategy in discovering or developing drug molecules with …

In silico methods for drug repurposing and pharmacology

RA Hodos, BA Kidd, K Shameer… - … Systems Biology and …, 2016 - Wiley Online Library
… generating and validating drug repurposing hypotheses. EHR … a large number of drug
repurposing hypotheses and analyze … generating novel drug repurposing hypotheses from EHR …

Drug Repurposing Hypothesis Generation Using the

K Regan, S Moosavinasab, P Payne, S Lin - JoVE (Journal of Visualized …, 2016 - jove.com
… the web-based drug repurposing hypothesis generation tool: "RE:fine Drugs." This protocol
can be modified to a user's preferences at the level of the query type (gene, drug or disease) …

REDIRECTION: Generating drug repurposing hypotheses using link prediction with DISNET data

AA Muñoz, EU Carro, LP Santamaría… - 2022 IEEE 35th …, 2022 - ieeexplore.ieee.org
… promising tool to generate drug repurposing hypotheses. … , drugs, and the relationships
between them. The main objective of REDIRECTION is to generate drug repurposing hypotheses