[HTML][HTML] A data-driven methodology towards evaluating the potential of drug repurposing hypotheses
LP Santamaría, EU Carro, MD Uzquiano… - Computational and …, 2021 - Elsevier
… in repurposing … actual repurposing-related information and non-repurposing data. The
insights obtained could be relevant when suggesting new potential drug repurposing hypotheses. …
insights obtained could be relevant when suggesting new potential drug repurposing hypotheses. …
Drug repurposing using real-world data
… Findings from this review support the idea that RWD can be used in drug repurposing for
hypothesis generation, hypothesis validation and safety assessment. In conjunction with the …
hypothesis generation, hypothesis validation and safety assessment. In conjunction with the …
Using human experience to identify drug repurposing opportunities: theory and practice
D Cavalla - British Journal of Clinical Pharmacology, 2019 - Wiley Online Library
… Although case reports are often the bases for repurposing hypotheses, they lack statistical
rigour and, for the purposes of this review, are not included in the definition of retrospective …
rigour and, for the purposes of this review, are not included in the definition of retrospective …
[HTML][HTML] Learning Drug-Disease-Target Embedding (DDTE) from knowledge graphs to inform drug repurposing hypotheses
We aimed to develop and validate a new graph embedding algorithm for embedding drug-disease-target
networks to generate novel drug repurposing hypotheses. Our model denotes …
networks to generate novel drug repurposing hypotheses. Our model denotes …
[HTML][HTML] The failure of drug repurposing for COVID-19 as an effect of excessive hypothesis testing and weak mechanistic evidence
… of drug repurposing for COVID-19 is susceptible to this problem. In unfavorable circumstances,
multiple comparisons can drastically impede true inferences. For example, Colhoun et al. …
multiple comparisons can drastically impede true inferences. For example, Colhoun et al. …
[HTML][HTML] Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects
M Chartier, LP Morency, MI Zylber… - BMC Pharmacology and …, 2017 - Springer
… drugs and 1216 unique potential cross-reactivity protein targets. We highlight a few cases
with a potential for drug repurposing (… -sites of the primary drug targets and visualise them for …
with a potential for drug repurposing (… -sites of the primary drug targets and visualise them for …
Drug repurposing (DR): an emerging approach in drug discovery
… Drug repurposing (DR)(also known as drug repositioning) is a process of identifying new …
/available drugs. It is an effective strategy in discovering or developing drug molecules with …
/available drugs. It is an effective strategy in discovering or developing drug molecules with …
In silico methods for drug repurposing and pharmacology
… generating and validating drug repurposing hypotheses. EHR … a large number of drug
repurposing hypotheses and analyze … generating novel drug repurposing hypotheses from EHR …
repurposing hypotheses and analyze … generating novel drug repurposing hypotheses from EHR …
Drug Repurposing Hypothesis Generation Using the
… the web-based drug repurposing hypothesis generation tool: "RE:fine Drugs." This protocol
can be modified to a user's preferences at the level of the query type (gene, drug or disease) …
can be modified to a user's preferences at the level of the query type (gene, drug or disease) …
REDIRECTION: Generating drug repurposing hypotheses using link prediction with DISNET data
AA Muñoz, EU Carro, LP Santamaría… - 2022 IEEE 35th …, 2022 - ieeexplore.ieee.org
… promising tool to generate drug repurposing hypotheses. … , drugs, and the relationships
between them. The main objective of REDIRECTION is to generate drug repurposing hypotheses …
between them. The main objective of REDIRECTION is to generate drug repurposing hypotheses …
相关搜索
- disease target drug repurposing hypotheses
- computational drug repurposing
- systematic review drug repurposing
- drug repurposing opportunities
- covid 19 drug repurposing
- drug repurposing method
- silico drug repurposing
- methods challenges and opportunities drug repurposing
- drug repurposing strategies
- legal and regulatory barriers drug repurposing
- known knowns drug repurposing
- academic researchers drug repurposing
- bigger haystack drug repurposing
- translational hurdles drug repurposing
- understanding side effects drug repurposing
- progress challenges and recommendations drug repurposing