… Taken together, pre-clinical studies can be useful in drug repurposing in the phase of
hypothesis generation. Through these studies, the pharmacological mechanism of a …

… suggests that all new repositioning hypotheses are false positives. This is not very straight-forward,
because computational methods for drug repurposing should predict new indications…

… However, these co-occurrence and network-based approaches also generate many
hypotheses, and identifying new drug indications from large networks can be time consuming. …

… candidates or suggest novel interventions based on drug-disease … based drug repurposing
focuses on drugs that are already approved and are used in clinical practice, such hypothesis …

… drug repurposing described stems from the work of researchers, who have formulated new
hypotheses (based on increasing knowledge of drug … ) and then tested these hypotheses in …

… discovery scheme comprised of three complementary components (computational drug
prediction, hypothesis-driven EHR-based testing, and mechanisms of action analyses), in which …

… The amyloid cascade hypothesis has been central to drug research, and a plethora of
drugs have been developed to target Aβ production and aggregation-associated pathologies. …

… the hypothesis that PDE5 inhibitor use reduces risk of incident ADRD. While wider use of
routinely collected healthcare data to evaluate biological hypotheses for drug repurposing is a …

… hypotheses for further testing. … We think that the Repurposing Library and Drug Repurposing
Hub will serve … search for new indications for existing drugs. We provide detailed sourcing …

… These networks help identify possible associations between functional pathways and ADRs
in the context of anti-inflammatory drugs that can be used to generate hypotheses regarding …