… and functions of SHP2, and briefly review the development of SHP2 inhibitors. Importantly, …
to overcome drug resistance and synergistic tumor immunotherapy using SHP2 inhibitors. We …

… of SHP2 inhibitors in 3D growth environments as compared to traditional 2D culture. In
vivo, SHP2 inhibition … with FGFR-targeted kinase inhibitors. Overall, we posit that combined …

… deletion prevents adaptive resistance to vemurafenib in BRAF-mutant colon cancer (14). …
suggest that SHP2 inhibition could provide a general strategy for preventing MEKi resistance in …

… the role of Shp2 in drug resistance has been partially revealed, Shp2 is … drug designs are
used to discover Shp2 inhibitors 96. Shp2 inhibitors play only a partial role, but these inhibitors …

… with agents (eg, MEK, KRAS, RTK, and PD-1/PD-L1 inhibitors) may produce less drug
resistance in patients compared with a single agent. (135,174) Though the importance of …

… While SHP2 inhibitors have exhibited promise in preclinical trials, numerous … drug
resistance. Although PROTAC-based SHP2 degraders show better efficacy than SHP2 inhibitors, …

… -resistant leukemia cells, we first revealed the novel role of SHP2 inhibitor by regulation the
co-interaction of SHP2, … that SHP2 inhibitors may be used as new therapeutic drugs for CML …

… ALK and SHP2 inhibition may provide a broad-reaching therapeutic strategy for overcoming
or preventing heterogeneous ALK-independent mechanisms of acquired drug resistance in …

… SHP2 with high selectivity and low toxicity are under development. This paper reviews
allosteric inhibitors of SHP2 … However, drug resistance is still a major challenge. The combination …

… Unfortunately, these patients develop drug resistance after treatment, due to acquired …
prevent EGFR inhibition, we sought to determine whether small molecule SHP2 inhibitors could be …