… revolutionized the treatment of severe rheumatoid arthritis (RA), yet drug discontinuation is
common. The aim of this study was to compare treatment retention rates and specific causes …

… with a higher risk of drug discontinuation [3, 4]… drug retention. Thus, the aim of this study is
to examine the association of time-varying disease outcome characteristics with drug retention …

… Among the most important observations in this study is the finding that drug retention rates
were significantly higher in patients treated with high doses of MTX (≥ 12.5 mg/week) or SSZ (…

… ABSTRACT Introduction: Disease-modifying anti-rheumatic drugs (DMARDs) currently
form the mainstay of treatment of rheumatoid arthritis (RA). We aimed to evaluate the retention …

… of Japanese Rheumatoid Arthritis Patients for Long-term Safety (REAL) database. Drug
retention rates were calculated using the Kaplan–Meier method. To compare risks of drug …

… not show significant influences on total drug retention, maybe due to uniformity of … drug
retention in this study, suggesting the impact of these factors in both TNFi and non-TNFi retention…

… drug metabolism and the presence of comorbid illnesses are emphasizing due to increasing
prevalence of rheumatoid arthritis … This study aimed to evaluate the retention rate and safety …

… This multi-center, retrospective study aimed to clarify the factors affecting drug retention of
… for drug discontinuation were classified into four major categories. The drug retention was …

… The primary outcome of this analysis was drug retention, which can be considered a proxy
for treatment effectiveness and treatment safety. Treatment exposure was defined as the …

… A 40-fold increase in drug retention in the joint was found, compared to injection of free MTX.
However, only 4% of the liposomal MTX was associated with the synovium. Liposomal MTX …