… drugs found their target against mutant forms of the EGFR … exquisite sensitivity of a subset
of these lung cancer mutants to … activation of the EGFR kinase by these mutants, and compare …

… mechanisms of drug tolerance of EGFR-mutated lung cancers … of an optimal treatment for
EGFR-mutated lung cancer will … highest sensitivities to EGFR TKIs, the vast majority of EGFR-…

… To address whether ErbB2 can modulate the sensitivity of EGFR to inhibitors we also …
stably expressing ErbB2 with the EGFR mutation library and selected for drug-resistant growth in …

… are known to render the development of novel targeted drugs … by EGFR and only a
subpopulation has an activating mutation (eg L858R), making them sensitive to first generation …

… To determine whether the observed effects of the TKIs on the different osimertinib-resistant
mutations in vitro correlated with in vivo drug sensitivity, we treated mice with EGFR L858R …

… NSCLC have revealed resistance mechanisms and drug sensitivity. In this review, we … EGFR
mutations. We will also focus on EGFR-TKI sensitivity in patients harboring EGFR mutations …

… EGFR mutation diversity and the efficacy of EGFR-TKIs for a subset of mutants prompted
us to apply our in silico drug sensitivity … sensitivity of two representative rare EGFR mutants, …

… to treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) (… with drug-sensitive EGFR
mutations such as EGFR exon 19 … mutation initially show satisfactory responsiveness to EGFR-…

… T854A was identified in one patient with a drug-sensitive EGFR L858R-mutant lung
adenocarcinoma after long-term treatment with TKI [53]. Growth inhibition assays using transfected …

… EGFR mutations are highly responsive to EGFR-TKIs, and the type of mutation correlates with
the sensitivity … Membrane transporters or drug efflux pumps can increase the sensitivity or …