A learning-based method for drug-target interaction prediction based on feature representation learning and deep neural network

J Peng, J Li, X Shang - BMC bioinformatics, 2020 - Springer
… We propose a learning-based method based on feature representation learning and deep
Drug targets are special molecules that can bind to drugs and produce effects in cells, the …

An end-to-end heterogeneous graph representation learning-based framework for drugtarget interaction prediction

J Peng, Y Wang, J Guan, J Li, R Han… - Briefings in …, 2021 - academic.oup.com
… ) is a powerful deep representation learning method for network data, … representation
learning-based framework, named EEG-DTI, to identify the interactions between drug and target. To …

Prediction of drug-target interactions based on multi-layer network representation learning

Y Shang, L Gao, Q Zou, L Yu - Neurocomputing, 2021 - Elsevier
… multilayer network representation learning method for drug-targetlearn the feature vectors
of drugs and targets. The feature vectors of the drug and the target are put into the drug-target

MultiDTI: drugtarget interaction prediction based on multi-modal representation learning to bridge the gap between new chemical entities and known heterogeneous …

D Zhou, Z Xu, WT Li, X Xie, S Peng - Bioinformatics, 2021 - academic.oup.com
… In our joint representation learning framework, we take the … drugs, targets, side effects and
diseases as constraints, and map the sequence representations of drugs and targets to the …

Prediction of drugtarget interactions based on network representation learning and ensemble learning

P Xuan, B Chen, T Zhang… - IEEE/ACM transactions on …, 2020 - ieeexplore.ieee.org
… side effects of drugs. We propose a network representation learning method based on matrix
factorisation to learn low-dimensional vector representations of drug and protein nodes. On …

A novel method to predict drug-target interactions based on large-scale graph representation learning

BW Zhao, ZH You, L Hu, ZH Guo, L Wang, ZH Chen… - Cancers, 2021 - mdpi.com
… Consequently, we constructed a large-scale graph representation learning network to
learn the features of each node, as shown in Figure 2. In which Figure 2A is the drug-target

GraphMS: drug target prediction using graph representation learning with substructures

S Cheng, L Zhang, B Jin, Q Zhang, X Lu, M You… - Applied Sciences, 2021 - mdpi.com
learning methods are also widely used in feature mapping [3], classification task [4] and disease
prediction [5]. Moreover, differentiable representation learningRepresentation Learning

DeepGS: Deep representation learning of graphs and sequences for drug-target binding affinity prediction

X Lin, K Zhao, T Xiao, Z Quan, ZJ Wang, PS Yu - ECAI 2020, 2020 - ebooks.iospress.nl
… Then, we introduce the representation learning for drugs and targets, respectively (Sections
2.2∼2.3). Finally, we discuss the binding affinity prediction with DeepGS (Section 2.4). …

Hierarchical graph representation learning for the prediction of drug-target binding affinity

Z Chu, F Huang, H Fu, Y Quan, X Zhou, S Liu… - Information …, 2022 - Elsevier
drugs interact with targets that is beneficial for predictive accuracy. In this paper, we propose
a novel hierarchical graph representation learning … hierarchical graph learning architecture …

Accurate prediction of molecular properties and drug targets using a self-supervised image representation learning framework

X Zeng, H Xiang, L Yu, J Wang, K Li… - Nature Machine …, 2022 - nature.com
… of downstream task related to molecular representation learning for testing: molecular
property prediction, drug metabolism prediction, drug–protein binding prediction and antiviral …