Adenosine receptors as drug targets—what are the challenges?
JF Chen, HK Eltzschig, BB Fredholm - Nature reviews Drug discovery, 2013 - nature.com
… of drugs causing adenosine receptor … adenosine signalling and drug effects over the
continuum of specific disease courses, addressing the implications for the use of adenosine receptor…
continuum of specific disease courses, addressing the implications for the use of adenosine receptor…
Adenosine receptors as drug targets
BB Fredholm - Experimental cell research, 2010 - Elsevier
… want to consider these receptors as potential drug targets it is … by endogenous adenosine
acting at the receptors in different … adenosine as an agonist at the different adenosine receptors…
acting at the receptors in different … adenosine as an agonist at the different adenosine receptors…
Adenosine receptors as therapeutic targets
KA Jacobson, ZG Gao - Nature reviews Drug discovery, 2006 - nature.com
… and antagonists of adenosine receptors have been discovered, … the roles of the various
adenosine receptor subtypes, and in the … of adenosine receptor modulators considerably closer. …
adenosine receptor subtypes, and in the … of adenosine receptor modulators considerably closer. …
Introduction to adenosine receptors as therapeutic targets
KA Jacobson - Adenosine receptors in health and disease, 2009 - Springer
… Although short-lived in the circulation, it can activate four subtypes of G protein-coupled
adenosine receptors (ARs): A 1 , A 2A , A 2B , and A 3 . The alkylxanthines caffeine and …
adenosine receptors (ARs): A 1 , A 2A , A 2B , and A 3 . The alkylxanthines caffeine and …
Adenosine receptors: targets for future drugs
JW Daly - Journal of medicinal chemistry, 1982 - ACS Publications
… of biological roles proposed for adenosine and for precursor adenine nucleotides … adenosine
receptors and adenine nucleotide receptors have been identified. The adenosine receptors …
receptors and adenine nucleotide receptors have been identified. The adenosine receptors …
Adenosine receptors as drug targets for treatment of pulmonary arterial hypertension
AKN Alencar, GC Montes, EJ Barreiro… - Frontiers in …, 2017 - frontiersin.org
… , and several new targets have … adenosine and adenosine receptors (A 1 , A 2A , A 2B , and
A 3 ) on the cardiovascular system, focusing on the A 2A receptor as a pharmacological target…
A 3 ) on the cardiovascular system, focusing on the A 2A receptor as a pharmacological target…
[HTML][HTML] Adenosine and its receptors as therapeutic targets: an overview
S Sachdeva, M Gupta - Saudi Pharmaceutical Journal, 2013 - Elsevier
… The four known adenosine receptor subtypes are discussed along with the therapeutic
potential indicating that these receptors can serve as targets for various dreadful diseases. …
potential indicating that these receptors can serve as targets for various dreadful diseases. …
Adenosine receptors as pharmacological targets
MD Erion - Annual Reports in Medicinal Chemistry, 1993 - Elsevier
… The anti-ischemic properties of adenosine suggest that adenosine receptors represent
potential drug targets for the treatment of acute myocardial infarction, angina, stroke and other …
potential drug targets for the treatment of acute myocardial infarction, angina, stroke and other …
The structure of the adenosine receptors: implications for drug discovery
JR Lane, VP Jaakola, AP IJzerman - Advances in pharmacology, 2011 - Elsevier
… receptors (GPCRs), the adenosine receptors (ARs). These ARs are important pharmacological
targets in the … Despite the innate tractability of GPCRs as drug targets, the 3D modeling of …
targets in the … Despite the innate tractability of GPCRs as drug targets, the 3D modeling of …
Adenosine: an old drug newly discovered
HK Eltzschig, DS Warner, MA Warner - The Journal of the American …, 2009 - pubs.asahq.org
… have used intravenous adenosine as mainstay … adenosine receptor therapeutics or
gene-targeted mice deficient in extracellular adenosine production or individual adenosine receptors …
gene-targeted mice deficient in extracellular adenosine production or individual adenosine receptors …
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