The use of multi-target drugs in the treatment of neurodegenerative diseases
CJ Van der Schyf - Expert review of clinical pharmacology, 2011 - Taylor & Francis
… the administration of an oral drug is particularly demanding Citation[23]. In neurodegenerative
diseases, current lead generation strategies utilize drug targets that are identified based …
diseases, current lead generation strategies utilize drug targets that are identified based …
Old drugs as new treatments for neurodegenerative diseases
F Durães, M Pinto, E Sousa - Pharmaceuticals, 2018 - mdpi.com
… for the most relevant neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s
disease, Huntington’s disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis. …
disease, Huntington’s disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis. …
NRF2 regulation processes as a source of potential drug targets against neurodegenerative diseases
Á Cores, M Piquero, M Villacampa, R León… - Biomolecules, 2020 - mdpi.com
… to the therapy of neurodegenerative diseases. NRF2 regulation … targets for the treatment of
neurodegenerative diseases, as … in terms of unexplored potential drug targets, and we hope …
neurodegenerative diseases, as … in terms of unexplored potential drug targets, and we hope …
[HTML][HTML] NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: what is the evidence?
S Sorce, R Stocker, T Seredenina, R Holmdahl… - Free Radical Biology …, 2017 - Elsevier
… Neurodegenerative disease are frequently characterized by … targets for the treatment of
neurodegeneration due to their role … many models of neurodegenerative diseases by using either …
neurodegeneration due to their role … many models of neurodegenerative diseases by using either …
The Nrf2-ARE Signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disorders
FL van Muiswinkel, HB Kuiperij - Current Drug Targets-CNS & …, 2005 - ingentaconnect.com
… target for neurodegenerative diseases, we advocate the view that chemopreventive agents
might be suitable candidates to serve as lead compounds for the development of a new class …
might be suitable candidates to serve as lead compounds for the development of a new class …
Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling
Y Wu, M Chen, J Jiang - Mitochondrion, 2019 - Elsevier
… feature of the neurodegenerative diseases is apoptosis … are involved in neurodegeneration.
Abnormal levels of these … the pathogenesis of neurodegenerative diseases. This review aims …
Abnormal levels of these … the pathogenesis of neurodegenerative diseases. This review aims …
Defining the neural kinome: strategies and opportunities for small molecule drug discovery to target neurodegenerative diseases
… new kinases as potential drug targets for neurodegenerative diseases will create opportunities
for … in other disease indications supports the idea that with the best targets identified small …
for … in other disease indications supports the idea that with the best targets identified small …
Prioritization of drug targets for neurodegenerative diseases by integrating genetic and proteomic data from brain and blood
YJ Ge, YN Ou, YT Deng, BS Wu, L Yang, YR Zhang… - Biological …, 2023 - Elsevier
… genetic and proteomic data to prioritize drug targets for neurodegenerative diseases. … 22
proteins as targets for neurodegenerative diseases and provided preliminary evidence for drug …
proteins as targets for neurodegenerative diseases and provided preliminary evidence for drug …
Phenotypic screening strategies for neurodegenerative diseases: a pathway to discover novel drug candidates and potential disease targets or mechanisms
RM Pruss - … -Drug Targets (Formerly Current Drug Targets-CNS …, 2010 - ingentaconnect.com
… in a preclinical animal model of the disease. These compounds then … neurodegenerative
disease targets and mechanisms, whether or not they have all the properties required of a drug …
disease targets and mechanisms, whether or not they have all the properties required of a drug …
Current therapeutic molecules and targets in neurodegenerative diseases based on in silico drug design
… This review attempts to recapitulate both current and novel drug targets in the principal
neurodegenerative diseases (AD, PD, ALS, and HD) using in silico approaches …
neurodegenerative diseases (AD, PD, ALS, and HD) using in silico approaches …
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