Mass spectrometry imaging for drugs and metabolites

T Greer, R Sturm, L Li - Journal of proteomics, 2011 - Elsevier
… , and LAESI for drug and metabolite imaging in biological … drugs and metabolites, but
interesting imaging studies of primary metabolites (AMP, ADP, ATP, etc.) and of plant metabolites

Qualitative and quantitative mass spectrometry imaging of drugs and metabolites

CB Lietz, E Gemperline, L Li - Advanced drug delivery reviews, 2013 - Elsevier
… detect and characterize drugs, metabolites, and endogenous drug-modified molecules in …
The aim of this review is to highlight the potential and realized benefits of drug and metabolite

Mass spectrometry imaging for drug distribution studies

B Prideaux, M Stoeckli - Journal of proteomics, 2012 - Elsevier
… distribution of both drug and its metabolites is of … drug from its metabolites (whole body
autoradiography). MSI is a sensitive and label-free approach for imaging drugs and metabolites in …

Desorption electrospray ionization mass spectrometry: Imaging drugs and metabolites in tissues

JM Wiseman, DR Ifa, Y Zhu… - Proceedings of the …, 2008 - National Acad Sciences
… for imaging because we did not expect to find the drug localized in the tissue substructure.
In each imaging … of data points in each row of the image is consistent. An import filter for data …

Quantitative mass spectrometry imaging of drugs and metabolites: a multiplatform comparison

L Lamont, D Hadavi, B Viehmann, B Flinders… - Analytical and …, 2021 - Springer
spectrometry imaging (MSI) has proven to be an invaluable tool for the pharmaceutical industry
to directly localize drugs and related metabolitesimaging for quantitative drug imaging in …

Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels

N Sun, A Walch - Histochemistry and Cell Biology, 2013 - Springer
… Mass spectrometry imaging (MSI) is a rapidly evolving … -active molecules and their metabolites
in tissue sections in situ. The … and quantitative MSI of drugs and metabolites in tissue at …

Mass spectrometry imaging in drug development

A Nilsson, RJA Goodwin, M Shariatgorji… - Analytical …, 2015 - ACS Publications
… radiolabeled version of the drug in male and … drug and metabolite levels). Data from such
investigations are used to assess potential exposures in human radiolabeled drug metabolism/…

[HTML][HTML] Mass spectrometry imaging in drug distribution and drug metabolism studies–Principles, applications and perspectives

JR Granborg, AM Handler, C Janfelt - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
imaging of drugs and their metabolites, primarily is studies of drug distribution and drug
metabolism. … fields within drug delivery (local and systemic) and drug metabolism with examples …

Imaging mass spectrometry for the assessment of drugs and metabolites in tissue

PJ Trim, S Francese, MR Clench - Bioanalysis, 2009 - Taylor & Francis
The study of drug distribution within biological tissue is a key part of the development of new
pharmaceuticals. Matrix-assisted laser desorption ionization–mass spectrometric imaging is …

Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: toward in situ pharmacometabolomes

Y Sugiura, M Setou - Journal of Neuroimmune Pharmacology, 2010 - Springer
… /ionization (MALDI) imaging mass spectrometry (IMS; also referred to as mass spectrometry
imaging) has attracted great interest for monitoring drug delivery and metabolism. Since this …