Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan
M Del Rio, F Molina, C Bascoul-Mollevi… - Journal of Clinical …, 2007 - ascopubs.org
… To determine gene signature, we kept only gene called present in at least 50% of the …
Data analysis was performed on the 19,365 expressed genes. Differentially expressed genes …
Data analysis was performed on the 19,365 expressed genes. Differentially expressed genes …
Genomic signatures to guide the use of chemotherapeutics
… In contrast, for those selected on the basis of Her2 … We suggest that the gene expression
signatures predicting … individual signatures can accurately predict response to drugs in …
signatures predicting … individual signatures can accurately predict response to drugs in …
Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies
Q Wen, P O'Reilly, PD Dunne, M Lawler… - BMC systems …, 2015 - Springer
… to query gene signatures, in order to evaluate similarity and identify potential drugs able to
alter the gene signature's … A query gene signature is a list of genes selected from biological …
alter the gene signature's … A query gene signature is a list of genes selected from biological …
Drug metabolism‐related eight‐gene signature can predict the prognosis of gastric adenocarcinoma
H Yin, Q He, J Chen, Z Li, W Yang… - Journal of Clinical …, 2021 - Wiley Online Library
… performed, and 11 drug metabolism-related prognostic DEGs were selected with p < 0.05, …
was performed to select the optimized gene set, and an eight-gene signature was identified, …
was performed to select the optimized gene set, and an eight-gene signature was identified, …
Mutational signatures are markers of drug sensitivity of cancer cells
J Levatić, M Salvadores, F Fuster-Tormo… - Nature …, 2022 - nature.com
… various mutational signatures and drug activity across cancer … established genetic markers
such as driver gene alterations. … We selected expression data for 1564 genes corresponding …
such as driver gene alterations. … We selected expression data for 1564 genes corresponding …
[HTML][HTML] Developing a genetic signature to predict drug response in ovarian cancer
… Instead, selection of drug combinations directed towards multiple cellular pathways associated
… cancer progression may provide a platform for preselection based on genetic signatures. …
… cancer progression may provide a platform for preselection based on genetic signatures. …
Gene signature critical to cancer phenotype as a paradigm for anticancer drug discovery
ER Sampson, HR McMurray, DC Hassane, L Newman… - Oncogene, 2013 - nature.com
… These genes were sub-selected from the list of genes differentially expressed between young
adult mouse colon (YAMC) cells and their malignant derivatives transformed with a pair of …
adult mouse colon (YAMC) cells and their malignant derivatives transformed with a pair of …
Utilization of genomic signatures to identify phenotype-specific drugs
… Gene expression signatures for RAS and PI3K used in this … of a gene expression signature
to distinguish basal or luminal cell type in breast cancers. Expression levels of selected genes …
to distinguish basal or luminal cell type in breast cancers. Expression levels of selected genes …
A gene expression signature associated with overall survival in patients with hepatocellular carcinoma suggests a new treatment strategy
… regarding these drugs, we performed an integrative clustering using the 45-gene signature in
… Two HCC cell lines randomly selected, HUH7 and PLC, which clustered with samples from …
… Two HCC cell lines randomly selected, HUH7 and PLC, which clustered with samples from …
Leveraging big data to transform target selection and drug discovery
… Instead of a signature built by comparing disease samples and normal samples, they built
a gene signature of metastatic potential by comparing nonmetastatic tumors vs. metastatic …
a gene signature of metastatic potential by comparing nonmetastatic tumors vs. metastatic …
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