Pharmacological mechanisms leading to synergy in fixed-dose dual bronchodilator therapy

L Calzetta, MG Matera, M Cazzola - Current Opinion in Pharmacology, 2018 - Elsevier
fixed-dose combinations (FDCs) are reported in Table 1. The bronchorelaxant effect of
long-acting bronchodilator … However, the differences in bronchodilation between first dose and …

[HTML][HTML] The role of fixed-dose dual bronchodilator therapy in treating COPD

A Anzueto, M Miravitlles - The American journal of medicine, 2018 - Elsevier
… the fixed-dose combination were more likely to exceed the threshold for clinically significant
SGRQ improvement than those receiving placebo or glycopyrrolate only. Numerical trends …

… safety profile of dual bronchodilation therapy in chronic obstructive pulmonary disease: a bidimensional comparative analysis across fixed-dose combinations

P Rogliani, MG Matera, BL Ritondo, I De Guido… - Pulmonary …, 2019 - Elsevier
… Despite dual bronchodilation therapy still represents the cornerstone therapy for most … -acting
muscarinic antagonist (LAMA) fixed-dose combinations (FDCs). Considering the change …

Fixed-dose combinations of long-acting bronchodilators for the management of COPD: global and asian perspectives

CK Rhee, H Yoshisue, R Lad - Advances in Therapy, 2019 - Springer
… of the available inhaled LABA/LAMA fixed-dose combinations (FDCs) for the treatment of …
selection of the optimal bronchodilation therapy with LABA/LAMA FDCs for COPD patients. …

Pharmacology of novel treatments for COPD: are fixed dose combination LABA/LAMA synergistic?

D Spina - European clinical respiratory journal, 2015 - Taylor & Francis
… Other long-acting bronchodilator drugs including mixed PDE3/4 inhibitors (Citation12); …
fixed dose combinations offer an advantage of either bronchodilator alone or in combinations, …

[HTML][HTML] A retrospective claims analysis of dual bronchodilator fixed-dose combination versus bronchodilator monotherapy in patients with chronic obstructive …

C Strange, V Walker, J Tong, J Kurlander… - … Diseases: Journal of …, 2019 - ncbi.nlm.nih.gov
combination bronchodilator therapies. Real world evidence for the benefits of combination
… (LABA) or dual therapy (DT) with a LAMA/LABA fixed dose combination (FDC) between …

LABA/LAMA fixed-dose combinations in patients with COPD: a systematic review

P Rogliani, L Calzetta, F Braido, M Cazzola… - … Journal of Chronic …, 2018 - Taylor & Francis
… As such, combining exercise training (to improve limb muscle fatigue) with double
bronchodilation may produce superior results in terms of exercise tolerance for COPD patients. …

Fixed-dose combination inhalers

M Cazzola, MG Matera - Pharmacology and Therapeutics of Asthma and …, 2017 - Springer
… seems to play an important role in optimizing bronchodilation. Several once-daily and
twice-daily LABA/LAMA FDCs have been developed or are in clinical development. LAMA/ICS …

Patient-reported outcomes of dual bronchodilator fixed-dose combination versus bronchodilator monotherapy in individuals with COPD

C Strange, V Walker, M DePietro, J Tong… - … Journal of Chronic …, 2019 - Taylor & Francis
… Individuals who initiate on a dual bronchodilator therapy are less likely to switch therapy
compared to individuals who initiate on a monotherapy bronchodilator. Participants in the dual

Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease

DP Tashkin, GT Ferguson - Respiratory research, 2013 - Springer
… A fixed-dose combination (FDC) of the short-acting agents … Additionally, dual bronchodilation
with ipratropium and albuterol … the optimal dosing for olodaterol added to a fixed dose of …