… shown that dual bronchodilation is a safe therapeutic approach and that it does not amplify
the possible AEs that are characteristic of LAMAs and LABAs when used as monotherapy. …

… on single long-acting bronchodilator therapy or LABA/LAMA combination therapy, who still
have … counts ≥300 cells·µL −1 , could benefit from ICS/LABA/LAMA combination therapy. …

… to single long-acting bronchodilator therapy and dual bronchodilator therapy; the “Outcomes” …
fixed or free LABA/LAMA combination and single long-acting bronchodilator therapy were …

… of triple therapy. It is therefore necessary to clarify when the use of triple therapy is indicated
in COPD patients and when it is preferable to maintain treatment with dual bronchodilation. …

… In the current SHINE study, we sought to confirm the “rule of combination” [12] that dual
bronchodilation with QVA149 will provide additional therapeutic benefits compared to the …

… combinations of bronchodilators of different … dual bronchodilator therapy, evidence for the
4 currently Food and Drug Administration-approved long-acting anticholinergic bronchodilators/…

… evidence regarding fixed triple therapy as a therapeutic option and we summarize … therapy
from dual bronchodilation to triple therapy and step down from triple to double bronchodilation …

… Randomized trials report that single-inhaler triple therapy is more effective than dual
bronchodilators … single-inhaler triple therapy with dual bronchodilators in real-world clinical …

… These data show that therapeutic intervention is effective in treatment-naïve patients.
Intervention with dual bronchodilator therapy as a first maintenance treatment for COPD may …

… = standard error; TRIBUTE = extrafine inhaled triple therapy versus dual bronchodilator
therapy in chronic obstructive pulmonary disease trial; TRINITY = single inhaler extrafine triple …