… increased pre-bronchodilator FEV 1 at the start of run-in (by 44 ml) and a slightly reduced
reversibility (by 3%), potentially representing less dual bronchodilator responsiveness, but …

… is recommended; however, as no fixed-dose dual bronchodilator was previously available,
… a dual bronchodilator therapy over a combination with ICS and showed that non-ICS therapy …

… To explore this further, we meta-analysed three RCTs that directly compared dual LAMA/LABA
therapy to triple therapy (supplementary figure S18). The pooled results revealed a higher …

… It would clearly be preferable if dual-acting bronchodilator treatments could demonstrate …
Mono- and combination therapy of long-acting bronchodilators and inhaled corticosteroids …

… impact of combined bronchodilator therapy on exacerbations … the benefits of dual bronchodilator
therapy versus single … the potential superior efficacy of dual bronchodilation to prevent …

… These developments, coupled with the emergence of effective dual bronchodilator therapies
(LABA/LAMA), led to revisions in the Global initiative for chronic Obstructive Lung Disease (…

… Dual bronchodilator therapy is recommended by the GOLD … However, when compared with
bronchodilator monotherapy, the … than 20 may also benefit from dual bronchodilator therapy. …

… Bronchodilator monotherapy is not always satisfactory for patients with advanced COPD. In
that situation, a dual-bronchodilator therapy consisting of LAMA and LABA is a good option. …

… shown that optimization of bronchodilation occurs when both … of both classes of bronchodilator
(dual bronchodilation) and an … in knowledge on bronchodilators and bifunctional drugs for …

… The following items represent the main findings of the study: Evening dosing of dual
bronchodilator was not associated with increased trough IC that was measured 12 h postdose at 8:…