Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB …

L Tan, Y Wang, G Ai, C Luo, H Chen, C Li… - International …, 2019 - Elsevier
Inflammation is a physiological response of immune defense system to protect the body …
However, exaggerated inflammatory response not only leads to the release of inflammation-…

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

MA Halili, MR Andrews, LI Labzin… - Journal of leukocyte …, 2010 - academic.oup.com
… We also assessed whether the divergent effects of TSA on inflammatory responses were …
This is likely a result of specific HDAC enzymes having an essential, dual function in cellular …

Harmful and beneficial effects of inflammatory response on reproduction: sterile and pathogen-associated inflammation

Y Negishi, Y Shima, T Takeshita… - Immunological medicine, 2021 - Taylor & Francis
… an excessive maternal inflammatory response without microbial … , inflammation can conversely
have beneficial effects on … HMGB1 has dual roles in sterile inflammation. It can act as a …

Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion

H Zhang, G Porro, N Orzech, B Mullen… - … of Physiology-Lung …, 2001 - journals.physiology.org
… from airway and blood have been reported in patients with inflammatory lung diseases, but
their exact role is unclear. We investigated the direct effect of defensins on the lungs of mice. …

Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism

KN Theken, Y Deng, MA Kannon, TM Miller… - Drug metabolism and …, 2011 - ASPET
… Although the mechanisms underlying these conflicting findings remain unclear, our data
suggest that dual inhibition of 20-HETE biosynthesis and sEH-mediated EET hydrolysis may be …

[HTML][HTML] Dual role of inflammatory mediators in cancer

TG Shrihari - Ecancermedicalscience, 2017 - ncbi.nlm.nih.gov
… for resolution of inflammation by the process of phagocytosis and apoptosis promote an
anti-inflammatory response. If inflammation or the inflammatory process is aggravated, …

Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases—C3 or C5 emerge together with CD14 as promising targets

A Barratt-Due, SE Pischke, PH Nilsson… - Journal of Leucocyte …, 2017 - academic.oup.com
… Importantly, all studied inflammatory responses, … in response to the dual inhibition of
complement and CD14, in accordance with the pronounced effect of the inflammatory response

Dual effects of hyperprolactinemia on carrageenan-induced inflammatory paw edema in rats

JE Ochoa-Amaya, BE Malucelli… - …, 2011 - karger.com
… had anti-inflammatory effects. Body weight was not affected … effects on the carrageenan-induced
inflammatory response. … regulation of the inflammatory response is important for immune …

Interleukin‐37: the effect of anti‐inflammatory response in human coronary artery endothelial cells

X Yan, B Xie, G Wu, J Hu, D Wang… - … of Inflammation, 2019 - Wiley Online Library
… As mentioned above, IL-37 is a “dual function” cytokine that exerts anti-inflammatory effects
both intracellularly and extracellularly. NF-κB is prevalent in the cells of the organism, and it …

Nanoparticles with dual responses to oxidative stress and reduced pH for drug release and anti-inflammatory applications

HL Pu, WL Chiang, B Maiti, ZX Liao, YC Ho, MS Shim… - ACS …, 2014 - ACS Publications
… Specifically, curcumin plays a critical role in controlling the signal transduction pathways
involved in inflammatory responses through the down-regulation of inflammatory transcription …