The dynamic nature of autophagy in cancer

AC Kimmelman - Genes & development, 2011 - genesdev.cshlp.org
… role of autophagy in cancer. Overall, the data support a dynamic role of autophagy in cancer—…
If the role of autophagy is indeed dynamic in human cancer, the regulation of this switch …

The role of autophagy in cancer

N Santana-Codina, JD Mancias… - … Review of Cancer …, 2017 - annualreviews.org
Autophagy can also be induced in response to … Therefore, targeting autophagy is an
attractive cancer … The mechanisms for autophagy activation in cancer cells and whether they are …

The role of autophagy in cancer development and response to therapy

Y Kondo, T Kanzawa, R Sawaya, S Kondo - Nature Reviews Cancer, 2005 - nature.com
AUTOPHAGY is a dynamic process in which intracellular membrane structures sequester
proteins and organelles to degrade and turn over these materials. It is an evolutionarily …

Cellular and metabolic functions for autophagy in cancer cells

CM Kenific, J Debnath - Trends in cell biology, 2015 - cell.com
… a dynamic regulator of tumorigenesis. Specifically, autophagy has been shown to impede
early cancer … Recent studies have uncovered several tumor-promoting functions for autophagy; …

Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues

K Tsuchihara, S Fujii, H Esumi - Cancer letters, 2009 - Elsevier
Autophagy is a dynamic process involving the bulk degradation of … of autophagy have been
also mentioned. Here, we will summarize and discuss recent studies of autophagy in cancer

Mechanisms and context underlying the role of autophagy in cancer metastasis

CM Dower, CA Wills, SM Frisch, HG Wang - Autophagy, 2018 - Taylor & Francis
nature of autophagy-mediated metastasis and provide direction for further research
investigating the role of autophagy in cancer … in autophagy are demonstrated during dynamic

Targeting autophagy in cancer

JMM Levy, CG Towers, A Thorburn - Nature Reviews Cancer, 2017 - nature.com
… question in cancer therapy: should we try to enhance autophagy or … of autophagy might
prevent cancer development 5 . Conversely, in advanced cancers, both enhancing autophagy

[HTML][HTML] A perspective on the role of autophagy in cancer

AR Ariosa, V Lahiri, Y Lei, Y Yang, Z Yin… - … et Biophysica Acta (BBA …, 2021 - Elsevier
… to the idea of autophagy as a double-edged sword when it comes to cancer therapy. This
review also briefly narrates how different types of autophagy—selective macroautophagy and …

[HTML][HTML] Role and regulation of autophagy in cancer

N Chen, V Karantza-Wadsworth - … et Biophysica Acta (BBA)-Molecular Cell …, 2009 - Elsevier
… , [61], and participate in vesicle formation and membrane dynamics. More recently, Bif-1 was
… Two more predictions pertain to the nature of the resultant apoptosis-and-autophagy doubly-…

[HTML][HTML] Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

L Vera-Ramirez, SK Vodnala, R Nini, KW Hunter… - Nature …, 2018 - nature.com
… from clinical trials addressing the clinical efficacy of autophagy inhibitors in cancer treatment.
Our data suggests that inhibition of autophagy may primarily affect survival of dormant/…