The dynamic nature of autophagy in cancer
AC Kimmelman - Genes & development, 2011 - genesdev.cshlp.org
… role of autophagy in cancer. Overall, the data support a dynamic role of autophagy in cancer—…
If the role of autophagy is indeed dynamic in human cancer, the regulation of this switch …
If the role of autophagy is indeed dynamic in human cancer, the regulation of this switch …
The role of autophagy in cancer
N Santana-Codina, JD Mancias… - … Review of Cancer …, 2017 - annualreviews.org
… Autophagy can also be induced in response to … Therefore, targeting autophagy is an
attractive cancer … The mechanisms for autophagy activation in cancer cells and whether they are …
attractive cancer … The mechanisms for autophagy activation in cancer cells and whether they are …
The role of autophagy in cancer development and response to therapy
Y Kondo, T Kanzawa, R Sawaya, S Kondo - Nature Reviews Cancer, 2005 - nature.com
… AUTOPHAGY is a dynamic process in which intracellular membrane structures sequester
proteins and organelles to degrade and turn over these materials. It is an evolutionarily …
proteins and organelles to degrade and turn over these materials. It is an evolutionarily …
Cellular and metabolic functions for autophagy in cancer cells
CM Kenific, J Debnath - Trends in cell biology, 2015 - cell.com
… a dynamic regulator of tumorigenesis. Specifically, autophagy has been shown to impede
early cancer … Recent studies have uncovered several tumor-promoting functions for autophagy; …
early cancer … Recent studies have uncovered several tumor-promoting functions for autophagy; …
Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues
K Tsuchihara, S Fujii, H Esumi - Cancer letters, 2009 - Elsevier
… Autophagy is a dynamic process involving the bulk degradation of … of autophagy have been
also mentioned. Here, we will summarize and discuss recent studies of autophagy in cancer …
also mentioned. Here, we will summarize and discuss recent studies of autophagy in cancer …
Mechanisms and context underlying the role of autophagy in cancer metastasis
… nature of autophagy-mediated metastasis and provide direction for further research
investigating the role of autophagy in cancer … in autophagy are demonstrated during dynamic …
investigating the role of autophagy in cancer … in autophagy are demonstrated during dynamic …
Targeting autophagy in cancer
JMM Levy, CG Towers, A Thorburn - Nature Reviews Cancer, 2017 - nature.com
… question in cancer therapy: should we try to enhance autophagy or … of autophagy might
prevent cancer development 5 . Conversely, in advanced cancers, both enhancing autophagy …
prevent cancer development 5 . Conversely, in advanced cancers, both enhancing autophagy …
[HTML][HTML] A perspective on the role of autophagy in cancer
… to the idea of autophagy as a double-edged sword when it comes to cancer therapy. This
review also briefly narrates how different types of autophagy—selective macroautophagy and …
review also briefly narrates how different types of autophagy—selective macroautophagy and …
[HTML][HTML] Role and regulation of autophagy in cancer
N Chen, V Karantza-Wadsworth - … et Biophysica Acta (BBA)-Molecular Cell …, 2009 - Elsevier
… , [61], and participate in vesicle formation and membrane dynamics. More recently, Bif-1 was
… Two more predictions pertain to the nature of the resultant apoptosis-and-autophagy doubly-…
… Two more predictions pertain to the nature of the resultant apoptosis-and-autophagy doubly-…
[HTML][HTML] Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence
… from clinical trials addressing the clinical efficacy of autophagy inhibitors in cancer treatment.
Our data suggests that inhibition of autophagy may primarily affect survival of dormant/…
Our data suggests that inhibition of autophagy may primarily affect survival of dormant/…
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