Early vs. non-early intervention in acute migraine—'Act when Mild (AwM)'. A double-blind, placebo-controlled trial of almotriptan

PJ Goadsby, G Zanchin, G Geraud… - …, 2008 - journals.sagepub.com
… almotriptan in migraine patients who take medication early in … significantly in favour of early
intervention with almotriptan, both … Treatment with almotriptan while migraine pain is still mild …

Treatment strategies in the acute therapy of migraine: stratified care and early intervention

D D'Amico, F Moschiano, S Usai, G Bussone - Neurological Sciences, 2006 - Springer
… to help clinicians provide the most effective acute treatment for migraine patients. Stratified
care is … that treating migraines with triptans when pain is mild (early intervention) considerably …

Almotriptan for the treatment of acute migraine: a review of early intervention trials

F Antonaci, I De Cillis, MG Cuzzoni… - Expert review of …, 2010 - Taylor & Francis
… efficacy in the acute treatment of migraine with … migraine onset, particularly when pain is
mild, rather than waiting until pain is moderate-to-severe. Benefits were also achieved with early

Early intervention with almotriptan improves sustained pain‐free response in acute migraine

NT Mathew - Headache: The Journal of Head and Face Pain, 2003 - Wiley Online Library
… of acute migraine, administration of the study drug was not limited to attacks of moderate or
severe pain. Patients were instructed to treat their migraine … for all phases of migraine attacks, …

Early treatment of acute migraine: new evidence of benefits

D Valade - Cephalalgia, 2009 - journals.sagepub.com
… of early intervention has become available. The AEGIS, AIMS and AwM studies of alrnotriptan
in patients with migraine … The opportunity to treat early exists for about 50% of all migraine

Cost-effectiveness analysis of early versus non-early intervention in acute migraine based on evidence from the 'Act when Mild'study

J Slof - Applied health economics and health policy, 2012 - Springer
migraine attacks. The specific objective of this article is to investigate the cost effectiveness
and cost utility of early intervention … to early and non-early treatment of acute migraine with …

Effect of early intervention with sumatriptan on migraine pain: retrospective analyses of data from three clinical trials

RK Cady, F Sheftell, RB Lipton, S O'Quinn, M Jones… - Clinical …, 2000 - Elsevier
… Results from The Spectrum Study suggested that early treatment of migraine attacks with …
Early intervention also resulted in less redosing than when moderate/severe pain was …

Influence of trigger factors on the efficacy of almotriptan as early intervention for the treatment of acute migraine in a primary care setting: the START study

M Leone, C Vila, C McGown - Expert review of neurotherapeutics, 2010 - Taylor & Francis
early intervention with 12.5 mg almotriptan significantly improved 2hPF and SPF rates in
migraine … regardless of the triggering factor provoking the migraine attack. This is an important …

Efficacy of almotriptan in early intervention for treatment of acute migraine in a primary care setting: the START* study

M Lanteri‐Minet, S Díaz‐Insa, M Leone… - … journal of clinical …, 2010 - Wiley Online Library
… reported 1174 migraine attacks, with early intervention being … took almotriptan early + mild
for their first migraine attack (n = … 12.5 mg taken early + mild for acute migraine (within 1 h of …

Multimechanistic (sumatriptan-naproxen) early intervention for the acute treatment of migraine

SD Silberstein, LK Mannix, J Goldstein, JR Couch… - Neurology, 2008 - AAN Enterprises
… The purpose of these studies was to evaluate the effectiveness of sumatriptan/naproxen
utilizing an early intervention treatment paradigm for the acute treatment of migraine evaluating …