The consequences of earlylife adversity: neurobiological, behavioural and epigenetic adaptations

S Maccari, HJ Krugers… - Journal of …, 2014 - Wiley Online Library
… Next, we consider the importance of the early postnatal … Finally, we review the evidence
for early-life adversity in … occurring in early life, be it pre- or postnatally, can have life-long …

The effects of early life adversity on the immune system

MMC Elwenspoek, A Kuehn, CP Muller… - …, 2017 - Elsevier
Early life adversity (ELA) is associated with a higher risk for diseases in adulthood. Although
the pathophysiological effects of ELA are varied, there may be a unifying role for the …

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome

NP Daskalakis, RC Bagot, KJ Parker… - …, 2013 - Elsevier
… with adversity accumulates. … early-life adversity prepares for the future and promotes
resilience to similar challenges in later-life; when a mismatch occurs between early and later-life

The stress acceleration hypothesis: Effects of early-life adversity on emotion circuits and behavior

BL Callaghan, N Tottenham - Current opinion in behavioral sciences, 2016 - Elsevier
… examined the effect of rearing adversity on the expression of … early life adversity also affects
the retention of such conditioned associations. For example, rats exposed to aversive early

[HTML][HTML] Early-life adversity and neurological disease: age-old questions and novel answers

AK Short, TZ Baram - Nature Reviews Neurology, 2019 - nature.com
… the statistical relationship between early-life adversity and a … primarily on how early-life
adversity could modulate cognitive … ,19,20,21,22 , and late-life dementia 17,18,23 . The types of …

Early life adversity and adult biological risk profiles

EM Friedman, AS Karlamangla… - Psychosomatic …, 2015 - journals.lww.com
… Although we find that educational attainment can compensate for early life socioeconomic
adversity, it must be noted that it is not so easy for everyone to obtain these higher levels of …

DNA methylation, behavior and early life adversity

M Szyf - Journal of Genetics and Genomics, 2013 - Elsevier
… The impact of early physical and social environments on life-long phenotypes is well known.
… on early life adversity. What are the mechanisms that embed these early life experiences in …

Measuring early life adversity: A dimensional approach

IS Berman, KA McLaughlin, N Tottenham… - Development and …, 2022 - cambridge.org
early life adversity. Here, we begin with mechanistic theories of early-life adversity and identify
a set of measures for which mechanisms have been proposed, and in some cases, tested. …

[HTML][HTML] The social ecology of childhood and early life adversity

M Lopez, MO Ruiz, CR Rovnaghi, GKY Tam… - Pediatric …, 2021 - nature.com
adversity may explain many long-term consequences, ‘stress’ is not the operative factor for
all observed outcomes. Instead, we prefer early life adversity (… for linking early adversities with …

Early-life adversity and cortisol response to social stress: a meta-analysis

IM Bunea, A Szentágotai-Tătar, AC Miu - Translational psychiatry, 2017 - nature.com
Early-life adversity has been associated with a life-long … time the effect of early-life adversity
on cortisol response to … -analysis, in which early-life adversity and salivary cortisol response …