Application of an in vitro dissolution/permeation system to early screening of oral formulations of poorly soluble, weakly basic drugs containing an acidic pH-modifier

M Mizoguchi, M Kataoka, K Yokoyama, R Aihara… - Journal of …, 2018 - Elsevier
… due to the inclusion of pH-modifiers are potential concerns. … of the pH-modifier, need to be
assessed at the early stage of … the D/P system to early screening of microenvironmental pH-…

Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with poor water solubility

PHL Tran, TTD Tran, KH Lee, DJ Kim… - Expert opinion on drug …, 2010 - Taylor & Francis
… Hence, the optimal choice is dependent on the specific drug and can be screened in a …
in the early stages of the test. Therefore, this technique is limited to samples in the dry solid-state. …

Development and evaluation of dipyridamole sustained release tablets containing micro-environmental pH modifiers

Z Xi, N Sharma, A Paprikar, S Lin - Journal of Drug Delivery Science and …, 2019 - Elsevier
… As displayed in Table 3, the drug content in all tablet formulations fabricated, based on
the outcomes of solid state stress stability studies from screening of various pH modifiers and …

Design and in vitro evaluation of novel sustained-release matrix tablets for lornoxicam based on the combination of hydrophilic matrix formers and basic pH-modifiers

YES Hamza, MH Aburahma - Pharmaceutical development and …, 2010 - Taylor & Francis
Full article: Design and in vitro evaluation of novel sustained-release matrix tablets for lornoxicam
based on the combination of hydrophilic matrix formers and basic pH-modifiers Skip to …

Mobile phase pH and organic modifier in reversed-phase LC–ESI-MS bioanalytical methods: assessment of sensitivity, chromatography and correlation of retention …

S Silvester - Bioanalysis, 2013 - Taylor & Francis
… organic modifier (despite elution now occurring in the early portion of the gradient). However,
excepting peak asymmetry under elution with MeOH, the markers indicated that greatest …

[图书][B] Screening for biological response modifiers: methods and rationale

JE Talmadge, IJ Fidler, RK Oldham - 2012 - books.google.com
… a recommendation very early on that screening capabilities be developed using human
cells to supplement the testing procedures being evaluated in the current screening process. …

Modifying matrix micro-environmental pH to achieve sustained drug release from highly laminating alginate matrices

AL Ching, CV Liew, LW Chan, PWS Heng - European journal of …, 2008 - Elsevier
… The action of pH-modifiers was synergistically enhanced in … of sodium chloride due to
screening effects and competition of … the early stages of hydration brought about by greater pH-…

Early detection of carcinogenic substances and modifiers in rats

N Ito, K Imaida, M Asamoto, T Shirai - Mutation Research/Reviews in …, 2000 - Elsevier
screening test for hepatocarcinogens consisting of three components: (1) DEN injection, (2)
test chemical administration and (3) PH … of the results, the timing of PH was fixed at week 3 in …

A high‐throughput assay for screening modifiers of calcium oxalate crystallization

S Ramamoorthy, JH Kwak, P Karande… - AIChE …, 2016 - Wiley Online Library
… , and microscopy have been limited to screening one-to-few … screening assay for identification
of crystal growth modifiers … temperatures and at near neutral pH in aqueous medium.52 …

Enhanced gastric stability of esomeprazole by molecular interaction and modulation of microenvironmental pH with alkalizers in solid dispersion

H Van Nguyen, N Baek, BJ Lee - International Journal of Pharmaceutics, 2017 - Elsevier
… greater absorption at the early stages. The current alkalizer-… under low pH conditions using
pH modifiers in powdered SD … screened to evaluate their effects on the EPM stability in pH