Early use of sarilumab in patients hospitalized with COVID-19 pneumonia and features of systemic inflammation: the SARICOR randomized clinical trial
N Merchante, S Cárcel, JC Garrido-Gracia… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
… the use of tocilizumab as the cumulative safety and efficacy with such a drug is larger than for
sarilumab and to consider the use of sarilumab as … use. Our study provides evidence for the …
sarilumab and to consider the use of sarilumab as … use. Our study provides evidence for the …
[HTML][HTML] Sarilumab use in severe SARS-CoV-2 pneumonia
… use of Sarilumab in patients with severe SARS-CoV-2-related pneumonia. In particular, the
study endpoints were to assess (i) the impact of Sarilumab … rate in patients treated in ICU care…
study endpoints were to assess (i) the impact of Sarilumab … rate in patients treated in ICU care…
Early Use of Sarilumab in Patients Hospitalized with COVID-19 Pneumonia and Features of Systemic Inflammation: the SARICOR Randomized Clinical Trial
N Merchante Gutiérrez, S Cárcel… - … , 66 (2), e0210721., 2022 - idus.us.es
… combining sarilumab at high doses with corticosteroids early on … In the meantime, it is
reasonable to prioritize the use of … than for sarilumab and to consider the use of sarilumab as an al…
reasonable to prioritize the use of … than for sarilumab and to consider the use of sarilumab as an al…
Two years of sarilumab in patients with rheumatoid arthritis and an inadequate response to MTX: safety, efficacy and radiographic outcomes
MC Genovese, J van Adelsberg, C Fan… - …, 2018 - academic.oup.com
… -IR patients received subcutaneous sarilumab (… , patients could enrol in the open-label,
long-term extension study (EXTEND, NCT011046652), in which all patients received sarilumab …
long-term extension study (EXTEND, NCT011046652), in which all patients received sarilumab …
Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study
… This study indicates that sarilumab is safe and effective in a specific subset of patients with
severe hyperinflamed COVID-19 presenting with low percentage of lung consolidation on CT …
severe hyperinflamed COVID-19 presenting with low percentage of lung consolidation on CT …
Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial
FX Lescure, H Honda, RA Fowler, JS Lazar… - The Lancet …, 2021 - thelancet.com
Background Elevated proinflammatory cytokines are associated with greater COVID-19 severity.
We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, …
We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, …
Efficacy and safety of early treatment with sarilumab in hospitalised adults with COVID-19 presenting cytokine release syndrome (SARICOR STUDY): protocol of a …
RL López, SC Fernández, LL Pérez, AR Palacios… - BMJ open, 2020 - bmjopen.bmj.com
… We propose that the early use of sarilumab, in addition to standard therapy, can attenuate
the detrimental host immune response in patients with elevated markers of inflammation by …
the detrimental host immune response in patients with elevated markers of inflammation by …
[HTML][HTML] Efficacy and safety of sarilumab in patients with COVID19 pneumonia: a randomized, phase III clinical trial (SARTRE study)
A Sancho-López, AF Caballero-Bermejo… - Infectious diseases and …, 2021 - Springer
… to evaluate if an early therapeutic intervention with sarilumab plus standard of care (… patients
with pneumonia. We also intend to provide data to support the safety of the use of sarilumab …
with pneumonia. We also intend to provide data to support the safety of the use of sarilumab …
Profile of sarilumab and its potential in the treatment of rheumatoid arthritis
MG Raimondo, M Biggioggero, C Crotti… - Drug Design …, 2017 - Taylor & Francis
… ) or IL-6 receptor (sarilumab). One Phase II and six Phase III … a broad efficacy of sarilumab
across all RA patient subtypes, … sarilumab as an alternative therapeutic option in RA patients. …
across all RA patient subtypes, … sarilumab as an alternative therapeutic option in RA patients. …
[HTML][HTML] Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol …
AF Caballero Bermejo, B Ruiz-Antorán… - Trials, 2020 - Springer
… with sarilumab … patients with interstitial pneumonia. This study will also provide supportive
evidence to that provided by currently ongoing studies on the efficacy and safety of sarilumab …
evidence to that provided by currently ongoing studies on the efficacy and safety of sarilumab …
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