Association of East Asian Variant Aldehyde Dehydrogenase 2 Genotype (ALDH2*2*) with Coronary Spasm and Acute Myocardial Infarction
H Yasue, Y Mizuno, E Harada - Aldehyde Dehydrogenases: From Alcohol …, 2019 - Springer
… -derived acetaldehyde and thereby protects tissues and cells from oxidative damage. Deficient
variant ALDH2*2 genotype is prevalent among East Asians … of toxic aldehydes, thereby …
variant ALDH2*2 genotype is prevalent among East Asians … of toxic aldehydes, thereby …
Origin and dispersal of atypical aldehyde dehydrogenase ALDH2⁎ 487Lys
HR Luo, GS Wu, AJ Pakstis, L Tong, H Oota, KK Kidd… - Gene, 2009 - Elsevier
… Combined with demographic history in East Asian, our results showed that the presence
of ALDH2⁎487Lys allele in peripheral regions of China might be the results of historical …
of ALDH2⁎487Lys allele in peripheral regions of China might be the results of historical …
A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2* 2 variant
ER Gross, VO Zambelli, BA Small… - Annual review of …, 2015 - annualreviews.org
… loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2. Found
in approximately 560 million people of East Asian descent, ALDH2*2 reduces enzymatic …
in approximately 560 million people of East Asian descent, ALDH2*2 reduces enzymatic …
East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing …
Y Mizuno, E Harada, S Morita, K Kinoshita… - Circulation, 2015 - Am Heart Assoc
… Coronary spastic angina (CSA) is a common disease among East Asians, including … of the
variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We …
variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We …
Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity
CH Chen, JCB Ferreira, AU Joshi, MC Stevens, SJ Li… - …, 2020 - thelancet.com
… A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) … , variant and
ALDH2*2 for the common East Asian E504K mutant variant) we designated these new variants …
ALDH2*2 for the common East Asian E504K mutant variant) we designated these new variants …
Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1
M Beretta, ACF Gorren, MV Wenzl, R Weis… - Journal of Biological …, 2010 - ASBMB
… acetaldehyde dehydrogenase activity of this variant. In the present study we compared the
wild type enzyme (ALDH2*1) with the Asian variant (… Alda-1 increased acetaldehyde oxidation …
wild type enzyme (ALDH2*1) with the Asian variant (… Alda-1 increased acetaldehyde oxidation …
Dominance of the inactive Asian variant over activity and protein contents of mitochondrial aldehyde dehydrogenase 2 in human liver
CL Lai, CT Yao, GY Chau, LF Yang… - Alcoholism: Clinical …, 2014 - Wiley Online Library
… a variant allele of mitochondrial aldehyde dehydrogenase 2 (ALDH2), ALDH2*2, commonly
occurs in East Asians … This unique allelic variation significantly influences drinking behavior …
occurs in East Asians … This unique allelic variation significantly influences drinking behavior …
Polymorphism of aldehyde dehydrogenase and alcohol sensitivity
HW Goedde, DP Agarwal - Enzyme, 1987 - karger.com
… 25 Eckey, R.; Agarwal, DP; Saha, N.; Goedde, HW: Detection and partial characterization
of a variant form of cytosolic aldehyde dehydrogenase isozyme. Hum. Genet. …
of a variant form of cytosolic aldehyde dehydrogenase isozyme. Hum. Genet. …
Association between aldehyde dehydrogenase 2 genetic polymorphism and serum lipids or lipoproteins: a meta-analysis of seven East Asian populations
PP Hao, L Xue, XL Wang, YG Chen… - …, 2010 - atherosclerosis-journal.com
… that studied East Asian populations to … variation and serum lipid and/or lipoprotein levels.
We found an association of ALDH2* 2 allele and low HDL-C concentration in East Asians. …
We found an association of ALDH2* 2 allele and low HDL-C concentration in East Asians. …
East Asian variant aldehyde dehydrogenase type 2 genotype exacerbates ischemia/reperfusion injury with ST-elevation myocardial infarction in men: possible sex …
T Ishida, Y Arima, Y Mizuno, E Harada, T Yamashita… - Heart and Vessels, 2022 - Springer
… Mitochondrial aldehyde dehydrogenase (ALDH2) is an enzyme detoxifying toxic aldehydes
… encoding deficient enzyme activity is prevalent in up to 40% among East Asians [8, 10]. …
… encoding deficient enzyme activity is prevalent in up to 40% among East Asians [8, 10]. …
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