One Health or Three? Transmission modelling of Klebsiella isolates reveals ecological barriers to transmission between humans, animals and the environment

H Thorpe, R Booton, T Kallonen, MJ Gibbon, N Couto… - BioRxiv, 2021 - biorxiv.org
… , community, animal and environmental settings in and around … across sources point to
ecological barriers that are likely to … We assigned the isolates to 15 described Klebsiella species, …

Limited transmission of Klebsiella pneumoniae among humans, animals, and the environment in a Caribbean Island, Guadeloupe (French West Indies)

A Dereeper, G Gruel, M Pot, D Couvin… - Microbiology …, 2022 - Am Soc Microbiol
Ecological barriers and/or limited exposure may restrict spread from the hospital setting to
… of novel resistance mechanisms in KpSC isolates from environmental sources, our findings …

[HTML][HTML] Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

KL Wyres, KE Holt - Current opinion in microbiology, 2018 - Elsevier
… all the ESKAPE pathogens can be isolated from environmental sources [57], however
systematic comparisons of isolation rates across environmental and animal sources are lacking. …

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health

KE Holt, H Wertheim, RN Zadoks… - Proceedings of the …, 2015 - National Acad Sciences
… human clinical isolates from plant, animal, or environmental isolates have … barriers to gene
flow among these closely related populations. These barriers could arise through ecological

A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings

HA Thorpe, R Booton, T Kallonen, MJ Gibbon… - Nature …, 2022 - nature.com
… genes and strains from environmental or agricultural settings … carefully sampled collections
of isolates holds the promise to … and ecological factors underpinning transmission barriers. …

Klebsiella pneumoniae population genomics and antimicrobial-resistant clones

KL Wyres, KE Holt - Trends in microbiology, 2016 - cell.com
… Unrooted maximum likelihood phylogenetic tree for 283 isolates … of isolates in different
locations. Curves show the discovery rate for new K. pneumoniae lineages as more isolates were …

Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy

MJ Martin, BW Corey, F Sannio… - Proceedings of the …, 2021 - National Acad Sciences
… By integrating genomic and epidemiological data for isolates collected over 20 mo, this …
, a barrier previously proposed as a reason for the relative rarity of convergent strains (3). …

Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae

KL Wyres, RR Wick, LM Judd, R Froumine… - PLoS …, 2019 - journals.plos.org
… The majority (87.6%) represented human clinical or carriage isolates from a range of … a
mechanistic barrier for DNA uptake in hypervirulent clones, but rather ecological characteristics …

Klebsiella pneumoniae: Prevalence, Reservoirs, Antimicrobial Resistance, Pathogenicity, and Infection: A Hitherto Unrecognized Zoonotic Bacterium

Y Hu, J Anes, S Devineau, S Fanning - Foodborne pathogens and …, 2021 - liebertpub.com
… susceptibility of Klebsiella isolates. Moreover, hypervirulent … hitherto unrecognized
environmental niche for Klebsiella and … epithelial barrier. (C) Elucidation of the mechanism used …

Evaluation of Potential Factors Influencing the Dissemination of Multidrug-Resistant Klebsiella pneumoniae and Alternative Treatment Strategies

T Ndlovu, L Kgosietsile, P Motshwarakgole… - Tropical Medicine and …, 2023 - mdpi.com
… of the environmental isolates are identical to clinical isolates … of resistance in regular
environmental Klebsiella species that are … the treatment barriers presented by multidrug …