Real-life gait assessment in degenerative cerebellar ataxia: Toward ecologically valid biomarkers

W Ilg, J Seemann, M Giese, A Traschütz, L Schöls… - Neurology, 2020 - AAN Enterprises
… , ecologically valid motor biomarkers are highly warranted. In this observational study, we
aimed to unravel and validate markers of ataxic gait in real life by using wearable sensors. …

Towards ecologically valid biomarkers: real-life gait assessment in cerebellar ataxia

W Ilg, J Seemann, M Giese, A Traschütz, L Schöls… - bioRxiv, 2019 - biorxiv.org
… motor markers for natural history and treatment trials in ecologically valid contexts. … -life
ataxic gait and hereby reflect disease severity, thus yielding promising ecologically valid outcome …

Ecological validity of a deep learning algorithm to detect gait events from real-life walking bouts in mobility-limiting diseases

R Romijnders, F Salis, C Hansen, A Küderle… - Frontiers in …, 2023 - frontiersin.org
… The clinical assessment of mobility, and walking specifically, is still mainly based on … that
lack ecological validity. Thanks to inertial measurement units (IMUs), gait analysis is shifting to …

Ecological validation of machine learning models for spatiotemporal gait analysis in free-living environments using instrumented insoles

TTH Duong, D Uher, J Montes… - IEEE Robotics and …, 2022 - ieeexplore.ieee.org
Ecological Validation We assessed the ecological validity of the ambulatory activity detection
… in degenerative cerebellar ataxia: Toward ecologically valid biomarkers,” Neurology, vol. 95…

Digital gait outcomes for ARSACS: discriminative, convergent and ecological validity in a multi-center study (PROSPAX)

L Beichert, W Ilg, C Kessler, A Traschuetz, S Reich… - medRxiv, 2024 - medrxiv.org
… a high degree of ecological validity of these outcome … in ecologically relevant contexts (walking
in public space). This combined convergent and ecological validity of our top-ranked gait

REVOLUTIONIZING COGNITIVE ASSESSMENT: THE POWER OF DIGITAL BIOMARKERS AND ECOLOGICALLY VALID METHODS

N Roque, M Sliwinski, M Katz… - Innovation in …, 2023 - academic.oup.com
… In presentation 1, Roque et al. examines the utility of ecological momentary cognitive
assessment and its potential as a digital biomarker of cognitive impairment in community-dwelling …

[HTML][HTML] An ecologically valid, longitudinal, and unbiased assessment of treatment efficacy in Alzheimer disease (the EVALUATE-AD Trial): proof-of-concept study

NWD Thomas, Z Beattie, J Marcoe… - JMIR Research …, 2020 - researchprotocols.org
… more sensitive, objective, and ecologically valid measures⸺digital biomarkers⸺need to be
… : continuous in-home unobtrusive gait assessment of older adults. Gait Posture 2012 Feb;35…

… Gait Outcomes for Autosomal Recessive Spastic Ataxia of Charlevoix‐Saguenay (ARSACS): Discriminative, Convergent, and Ecological Validity in a Multicenter …

L Beichert, W Ilg, C Kessler, A Traschütz… - Movement …, 2024 - Wiley Online Library
… a high degree of ecological validity of these outcome … ecologically relevant contexts (walking
in public spaces). This combined convergent and ecological validity of our top-ranked gait

Prediction of injurious falls in older adults using digital gait biomarkers extracted from large-scale wrist sensor data

LLY Chan, CH Arbona, MA Brodie, SR Lord - Age and ageing, 2023 - academic.oup.com
ecological validitygait biomarker and injurious falls was first examined with univariable
Cox regression. Subsequently, multi-collinearity between digital gait biomarkers was assessed

Quantitative gait and balance outcomes for ataxia trials: consensus recommendations by the ataxia global initiative working group on digital-motor biomarkers

, … Initiative (AGI) working group Digital Motor Biomarkers - The Cerebellum, 2023 - Springer
… , ecologically valid, finely granulated, digital health measures are highly warranted to augment
clinical and patient-reported outcome measures. Gait and … Thus, digital gait and balance …