… We propose that cancer therapy become as dynamic as the tumor system being treated.
Ideally, treatment strategies should anticipate, corral, and stay ahead of the intratumoral …

… resistant cancer cells that now grow and fill the space left by the now dying sensitive cells; (2)
as the populations of sensitive cancer … view cancer therapy, evolution of therapy resistance …

… that accounts for cancer stem cells, highlighting the role of niche specificity in CSC therapy
resistance. We show that the lessons learnt from metapopulation ecology can help guide …

… Although conventional cancer therapies have been effective in killing cancer cells, this
approach has failed to cure cancer because of the evolution of resistance, metastasis, and often …

… In order to design effective cancer therapies, we need to know the proportion of subpopulations
of cancer cells differing in their resistance mechanisms. For example, there are three cell …

… We hypothesize that cancer cells form local ecological communities within tumors. The cancer
… then there is a kind of food-safety tradeoff between the sensitive and resistant cancer cell …

… during cancer therapy, the theory behind adaptive therapy … mechanism(s) of resistance.
Proliferation of any phenotype in an … and ecological dynamics serve as first principles in cancer …

… therapy-resistant clones in their heterogeneous makeup. The design of many therapeutic …
In the context of cancer therapy, these results suggest that a cooperatively growing tumour …

… acquired therapeutic resistance because cytotoxic therapy inevitably selects for resistant …
At the same time, prognosis for young cancer patients is typically more favorable, which can …

… cell types are more resistant to cancer or metastasis. It has been suggested that disturbance
creates pools of unused resources needed by invaders in ecology [25] or in cancer [28] or …