Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries

HJ Taylor, AT Chaytor, DH Edwards… - … and biophysical research …, 2001 - Elsevier
… In the present study we have used rabbit artery and vascular bed preparations to test the …
encompass several characteristics of the “EDHF phenomenon” noted above. These include (i) …

Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses

C De Wit, TM Griffith - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
… In isolated rabbit arteries, EDHF-type relaxations are associated with NO- and prostanoid-independent
elevations in smooth muscle cAMP levels that peak ∼15-30 s after exposure to …

The alternative: EDHF

M Félétou, PM Vanhoutte - Journal of molecular and cellular cardiology, 1999 - Elsevier
… restricted to describe phenomena in which endoit disappears in K+ … in EDHFmediated
relaxation in cerebral arteries. Br J Pharmacol polarization of rabbit mesenteric arteries via ATP-…

EDHF: spreading the influence of the endothelium

CJ Garland, CR Hiley, KA Dora - British journal of …, 2011 - Wiley Online Library
… So the EDHF phenomenon came to be recognized as smooth muscle relaxation in blood …
arteries used in this study were the rat hepatic and mesenteric arteries, and while the EDHF

EDHF: bringing the concepts together

R Busse, G Edwards, M Félétou, I Fleming… - Trends in …, 2002 - cell.com
EDHF phenomenon: (1) the increase in endothelial [Ca 2+ ] i triggers the synthesis of a
cytochrome P450 metabolite that is essential for the subsequent EDHF-… the EDHF phenomenon

EDHF: new therapeutic targets?

M Félétou, PM Vanhoutte - Pharmacological research, 2004 - Elsevier
… This phenomenon is endothelium-dependent, but although nitric oxide is involved in some
… renal arteries of hypercholesterolemic rabbits an enhancement of the contribution of EDHF

Connexin‐mimetic peptides dissociate electrotonic EDHF‐type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery

AT Chaytor, LM Bakker, DH Edwards… - British journal of …, 2005 - Wiley Online Library
… the EDHF phenomenon is electrotonic in nature, and highlight the contribution of myoendothelial
and homocellular smooth muscle communication via gap junctions to arterial function. …

[PDF][PDF] Factors, fiction and endothelium-derived hyperpolarizing factor-EDH (F)

SL Sandow - Proceedings of the Australian Physiological and …, 2004 - aups.org.au
… for MEGJs in the action of K+ as EDHF.However, once a role for … diffusible EDHF may be
redundant, since the EDHF phenomenonartery of the rabbit, apamin alone abolished the EDHF

EDHF: an update

M Félétou, PM Vanhoutte - Clinical science, 2009 - portlandpress.com
… substances can be built in specific arteries and especially in those of the rabbit, most of
the … size of the artery [147], a phenomenon that parallels the contribution of the EDHF-mediated …

Factors, fiction and endothelium‐derived hyperpolarizing factor

SL Sandow - Clinical and Experimental Pharmacology and …, 2004 - Wiley Online Library
… as EDHF. However, once a role for MEGJ is included in this mechanism, a role for K + as a
diffusible EDHF may be redundant, because the EDHF phenomenon … In the rabbit iliac artery, …