Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation

ZQ Xu, TJ Shi, M Landry, T Hökfelt - Neuroreport, 1996 - journals.lww.com
… that the action of galanin in the dorsal horn is mainly postsynaptic, that is on receptors expressed
in … In the present study we demonstrate that the first cloned galanin receptor, GAL-R1, is …

Expression and regulation of galanin-R2 receptors in rat primary sensory neurons: effect of axotomy and inflammation

TJS Shi, X Zhang, K Holmberg, ZQD Xu, T Hökfelt - Neuroscience letters, 1997 - Elsevier
… Using in situ hybridization, we studied galanin-R2 receptor (… and sciatic nerve transection
(axotomy). About 25% of all … a long-lasting decrease after axotomy. These results, together with …

On the role of galanin, substance P and other neuropeptides in primary sensory neurons of the rat: studies on spinal reflex excitability and peripheral axotomy

XJ Xu, Z Wiesenfeld‐Hallin, MJ Villar… - European Journal of …, 1990 - Wiley Online Library
… Our recent and present results support the observation that the facilitatory effect of a C-fibre
input is unchanged after axotomy. However, we propose that the role of SP has been taken …

Galanin receptor binding sites in adult rat spinal cord respond differentially to neonatal capsaicin, dorsal rhizotomy and peripheral axotomy

S Kar, R Quirion - European Journal of Neuroscience, 1994 - Wiley Online Library
… The present results demonstrate the topographic distribution of [12sI]galanin receptor binding
sites in the rat lumbar spinal cord and its alteration following various pharmacological and …

Galanin in Somatosensory Function a

Z WIESENFELD‐HALLIN… - Annals of the New York …, 1998 - Wiley Online Library
… , and we have shown that following axotomy galanin may be tonically active in inhibiting …
is of interest in understanding its mechanism of action in axotomized rats. Galanin receptors

… effects of axotomy and preganglionic denervation on the expression of pituitary adenylate cyclase activating peptide (PACAP), galanin and PACAP type 1 receptors in …

K Moller, M Reimer, E Ekblad, J Hannibal… - Brain research, 1997 - Elsevier
… possible effects of tissue traumatization after surgical axotomy, we also examined the effects
… ]on PACAP-, GAL- and PACAP type 1 receptor expression. Here we report that PACAP and …

Galanin induced in sympathetic neurons after axotomy is anterogradely transported toward regenerating nerve endings

AM Shadiack, RE Zigmond - Neuropeptides, 1998 - Elsevier
… neurons begin to express galanin after axotomy. When neurons … axotomized near (about
2 mm) from the ganglion, galanin-like immunoreactivity (IR) was maximal within 72 h. Axotomy

Galanin receptor subtypes

TA Branchek, KE Smith, C Gerald… - Trends in pharmacological …, 2000 - cell.com
… of physiological effects. Pharmacological … galanin fragments with galanin receptors on
isolated smooth muscle cells from guinea pig stomach: identification of a novel galanin receptor

The participation of galanin in pain processing at the spinal level

HX Liu, T Hökfelt - Trends in pharmacological sciences, 2002 - cell.com
… -nociceptive effect of galanin is related to presynaptic galanin GAL2 receptors on primary …
is distinctly changed by axotomy because GAL1 receptor and GAL2 receptor mRNA levels are …

Neuropeptide Y and Galanin Binding Sites in Rat and Monkev Lumbar Dorsal Root Ganalia and Spinal Cord and Effect of Peripheral Axotomy

X Zhang, RR Ji, S Nilsson, M War… - European Journal of …, 1995 - Wiley Online Library
Galanin receptor binding sites were not observed in rat DRG, but were observed in the …
Axotomy had no effect on galanin binding in rat DRG and dorsal horn. However, galanin receptor