[HTML][HTML] Erlotinib in previously treated non–small-cell lung cancer

FA Shepherd, J Rodrigues Pereira… - New England journal …, 2005 - Mass Medical Soc
… factor receptor inhibitor erlotinib prolongs survival in non–small-cell lung cancer after the …
), in favor of erlotinib. Five percent of patients discontinued erlotinib because of toxic effects. …

Effects of Erlotinib in EGFR Mutated Non-Small Cell Lung Cancers with Resistance to Gefitinib

DB Costa, KSH Nguyen, BC Cho, LV Sequist… - Clinical cancer …, 2008 - AACR
… Purpose: Most lung cancers with activating epidermal growth factor … effects of erlotinib 150
mg/d in EGFR mutated patients resistant to gefitinib 250 mg/d, because the EGFR TKI erlotinib

[HTML][HTML] Erlotinib in lung cancer—molecular and clinical predictors of outcome

MS Tsao, A Sakurada, JC Cutz, CQ Zhu… - … England Journal of …, 2005 - Mass Medical Soc
… to erlotinib and its impact on survival were associated with expression by the … survival
benefit from erlotinib. To clarify the role of EGFR in the outcome of non–small-cell lung cancer, we …

Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non–small cell lung cancer cells

T Li, YH Ling, ID Goldman, R Perez-Soler - Clinical cancer research, 2007 - AACR
… Pemetrexed and erlotinib monotherapy have different mechanisms of action and similar
clinical effectiveness compared with docetaxel but their main advantage is mild toxicity and …

Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer

Y Li, S Lam, JC Mak, C Zheng, JC Ho - Lung cancer, 2013 - Elsevier
… In this study, we investigated the effect of erlotinib treatment on autophagy in 4 NSCLC cell
lines with different EGFR mutation status, in order to understand the possible mechanisms …

Effect of erlotinib plus bevacizumab vs erlotinib alone on progression-free survival in patients with advanced EGFR-mutant non–small cell lung cancer: a phase 2 …

TE Stinchcombe, PA Jänne, X Wang, EM Bertino… - JAMA …, 2019 - jamanetwork.com
… Question Is the combination of erlotinib and bevacizumab superior to erlotinib alone to
treat epidermal growth factor receptor (EGFR)–mutant non–small cell lung cancer? …

Erlotinib: a new therapeutic approach for non-small cell lung cancer

P Bonomi - Expert opinion on investigational drugs, 2003 - Taylor & Francis
… in patients with stage III and IV non-small cell lung cancer (NSCLC), it appears that a plateau
has … tyrosine kinases show that erlotinib had little inhibitory effect. Higher concentrations of …

Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure‐safety relationship in patients with non–small cell lung cancer

JF Lu, SM Eppler, J Wolf, M Hamilton… - Clinical …, 2006 - Wiley Online Library
… and erlotinib exposure in non-small cell lung cancer patients treated with single-agent erlotinib.
Effects of covariates on erlotinib clearance and correlations with adverse event severity …

Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models

B Higgins, K Kolinsky, M Smith, G Beck… - Anti-cancer …, 2004 - journals.lww.com
… kinase inhibitor erlotinib in athymic nude mice bearing non-small cell lung cancer (NSCLC) …
Effect of erlotinib on mean tumor volume in the H460a NSCLC xenograft model. Mice were …

[HTML][HTML] The concentration of erlotinib in the cerebrospinal fluid of patients with brain metastasis from non‑small‑cell lung cancer

Y Deng, W Feng, J Wu, Z Chen… - Molecular and …, 2014 - … .spandidos-publications.com
… curative effect of erlotinib on non-small-cell lung cancer with … of erlotinib in the cerebrospinal
fluid exerting a curative effect … from non-small-cell lung cancer, even when treated with the …