… The action of E2 has been traditionally explained by the binding to the estrogen receptor (ER)
α and ERβ, however the G protein-coupled receptor (GPR) 30 has been recently involved …

… and effects of E, in vitro and in vivo. In these tissues and cells, E, has modest affinity for …
In human endometrium, we find that E, has an affinity for estrogen receptor 12% that of E, and …

… In vim dissociation of these 2 estrogens from this nuclear bound receptor formed in viva …
5s estrogen receptor complexes causes rapid dissociation of E, or E,; this effect is dose-…

… receptor produces the second, slower phase (9). In this report we analyze the binding kinetics
of estradiol, estriol, and estrone to the estrogen receptor … and effects on estrogen receptor …

… to the estrogen receptor. We studied the effects of estriol and estrone on the positive
cooperativity of ['Hlestradiol binding to the partially purified, calf uterine estrogen receptor. The …

… We used an established in vitro cell culture assay and compared the effect of E2 and E3
on growth of the estrogen receptor alpha-positive breast cancer cell lines MCF-7 and T-47D …

… No or weak protective effects of estriol and estrone are observed for … estriol and estrone,
compared to 17β-E2, could explain the lack of weak neuroprotective activity of these estrogenic …

… of the fact that estriol competes rather poorly with estradiol for receptor binding. However, …
above, it is of interest to examine the postulated protective effect of estriol more closely. As …

… of estrogen receptor complexes to specific sequences in gene promoters (genomic effects),
or by … The hydroxylation of estradiol or 16α-hydroxyestrone forms estriol. In addition, catechol …

… We conclude that estniol can bind to estrogen receptor and stimulate human breast
cancer in tissue culture. Our data do not support an antiestnogenic role for estniol in human …