… It is clear that tumor cells do not act alone but in close interaction with the extracellular matrix
and with stromal cells in the tumor microenvironment (TME). As our understanding of tumor …

… To ensure an efficient drug delivery to tumor cells in an acidic TME, current clinical trials
propose … clinical trials using Mifamurtide, an observational study (NCT03737435) to analyze the …

… studies can estimate the immunological frequency and cellular status in the tumor
microenvironment, … potential for substantial clinical effects are driving thousands of clinical trials. …

… studies, meta-analyses, clinical trials, cohort studies, and systematic reviews. The articles
were carefully examined for applicability to the study … and effectiveness of cancer management …

… together to impede effective antitumor immunity and promote breast cancer progression and
… clinical trials. We focus herein on the composition of the breast cancer microenvironment …

… tumor microenvironment into consideration. Besides, we also discuss the limitations of current
pre-clinical testing … for explaining how cancer finally turns the effective drug into a failure. …

… are simultaneously inhibited, may offer a more efficient way to treat cancer by circumventing
… results in animal models, and some of these drugs are now in clinical trials (reviewed in …

… Several compounds capable of inhibiting hypoxia inducible factor-1 (HIF-1) or its targets
have shown competence in inhibiting tumor progression and are in clinical trials Fig. 2B. For …

… on macrophages Clinical trials in phase I and few in phase II; studies are at an early
stage … II study (NCT01349036) showed good drug tolerance and penetration of the blood–tumor …

… to improve the effectiveness of drug treatment by modifying factors relating to the TME. …
Although integrins remain a potential target for cancer therapy, clinical trials have shown …