238 天前 - … in the liver and 27 heart. Reduced adiposity was associated with decreased serum
glucose and insulin, and increased 28 insulin-stimulated glycogenesis in skeletal muscle. In …

245 天前 - … IGFBP7 has been linked to heart failure-associated cell senescence. … reversed
this effect, indicating that IGFBP7 in the CM mediates the inhibitory effect on IGF-1 signaling. …

245 天前 - … LASSO outperformed other models in discrimination for MACE (AUC = 0.75) and
prioritized tetranectin (an adipocyte secretory protein associated with insulin resistance and …

251 天前 - … , skeletal muscle, and pancreas, and which may affect insulin … (CKD) mortality, but
the effect was perceived as too little, … the effect by simultaneously lowering resting heart rate (…

251 天前 - … The kidney is second only to the heart in mitochondrial … Here we examined the role
of muscle mediator, signal … body weight, intracellular insulin signaling in peripheral tissues, …

256 天前 - … Body mass index and mortality in acutely decompensated heart failure across the
world… their skeletal muscle phenotype differed with a higher IMAT% and lower skeletal muscle …

257 天前 - … Both therapies target diverse physiological mechanisms, with SGLT2i’s inhibiting
renal glucose reabsorption causing glycosuria, while GLP-1’s stimulate insulin production, …

258 天前 - … to current CR practice and benefit both muscle and cardiovascular health. Meta-…
beneficial but variable effects regarding weight loss, the lipid profile, insulin resistance and lean …

262 天前 - … , heart failure… effects on distant organs. For example, adipocyte-derived extracellular
vesicles (AdEVs) can either impair or enhance insulin sensitivity in hepatocytes and muscle …

265 天前 - … insulin sensitivity, a higher waist-hip ratio, and worse vascular function. However,
the effects … They also prespecified a secondary analysis for heart failure alone. The study was …