Duration of treatment among patients prescribed afatinib or erlotinib as first-line therapy for EGFR mutation-positive non-small-cell lung cancer in the USA

J Lim, C Samuelsen, A Golembesky, S Shrestha… - Future …, 2019 - Taylor & Francis
… While randomized controlled trials are conducted to assess the efficacy and safety of …
have been shown to be lower than efficacy estimates from randomized controlled trials [Citation26]. …

Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized …

P Frohna, J Lu, S Eppler, M Hamilton… - The Journal of …, 2006 - Wiley Online Library
… tested in this study, six 25-mg tablets and one 150-mg tablet, are bioequivalent, so
plasma exposure and efficacy will not be affected if 25-mg tablets are substituted for a dose. …

Activity of erlotinib when dosed below the maximum tolerated dose for EGFR‐mutant lung cancer: Implications for targeted therapy development

BL Lampson, M Nishino, SE Dahlberg, D Paul… - Cancer, 2016 - Wiley Online Library
… On the basis of the in vitro data described above, we hypothesized that reduced-dose
erlotinib has similar efficacy to the MTD of erlotinib and represents a viable treatment option for …

Budget impact of erlotinib for maintenance therapy in advanced non-small cell lung cancer

JJ Carlson, WB Wong, DL Veenstra… - Journal of Medical …, 2011 - Taylor & Francis
erlotinib maintenance therapy was given, the use of pemetrexed and docetaxel increased in
2nd-line therapy due to our assumption that patients would not be given erlotinib in … efficacy

Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non–small-cell lung cancer: a phase III trial

GV Scagliotti, M Krzakowski, A Szczesna… - Journal of clinical …, 2012 - ascopubs.org
… be efficacious. Nonclinical evidence from NSCLC xenograft models suggests that sunitinib
increases the antitumor activity of erlotinib. … the efficacy and safety of sunitinib plus erlotinib in …

[HTML][HTML] Efficacy and safety of anti-angiogenic drugs combined with erlotinib in the treatment of advanced non-small cell lung cancer: a meta-analysis of randomized …

Z Chen, S Jiang, X Li, J Zhang, L Liu… - Annals of Palliative …, 2021 - apm.amegroups.org
… explored the efficacy and safety of VEGF neutralizing antibodies, combined with erlotinib. …
was to explore the efficacy and safety of combined medications, and simultaneously to conduct …

Erlotinib in the treatment of recurrent or metastatic cutaneous squamous cell carcinoma: a single‐arm phase 2 clinical trial

KA Gold, MS Kies, WN William Jr, FM Johnson… - Cancer, 2018 - Wiley Online Library
… the closely related EGFR tyrosine kinase inhibitor erlotinib. Erlotinib 150 mg daily was more
… it was important to establish the efficacy of erlotinib monotherapy with a phase 2 single-arm …

Final survival and safety results from a multicenter, open‐label, phase 3b trial of erlotinib in patients with advanced nonsmall cell lung cancer

DR Spigel, M Lin, V O'Neill… - … International Journal of …, 2008 - Wiley Online Library
Erlotinib is an … of erlotinib in patients with advanced NSCLC who had progressed after
standard chemotherapy treatment was conducted to examine the efficacy and safety of erlotinib

Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double …

RS Herbst, R Ansari, F Bustin, P Flynn, L Hart… - The Lancet, 2011 - thelancet.com
… Bevacizumab and erlotinib target different tumour growth … of erlotinib plus bevacizumab
for recurrent or refractory non-small-cell lung cancer (NSCLC), we aimed to assess efficacy and …

[HTML][HTML] A randomized phase II study comparing erlotinib versus erlotinib with alternating chemotherapy in relapsed non-small-cell lung cancer patients: the NVALT-10 …

JG Aerts, H Codrington, NAG Lankheet, S Burgers… - Annals of oncology, 2013 - Elsevier
… or pemetrexed and intermitted erlotinib with single-agent erlotinib in second-line treatment
of NSCLC are available in the current literature. The increased efficacy of combining these …