Duration of treatment among patients prescribed afatinib or erlotinib as first-line therapy for EGFR mutation-positive non-small-cell lung cancer in the USA
J Lim, C Samuelsen, A Golembesky, S Shrestha… - Future …, 2019 - Taylor & Francis
… While randomized controlled trials are conducted to assess the efficacy and safety of …
have been shown to be lower than efficacy estimates from randomized controlled trials [Citation26]. …
have been shown to be lower than efficacy estimates from randomized controlled trials [Citation26]. …
Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized …
P Frohna, J Lu, S Eppler, M Hamilton… - The Journal of …, 2006 - Wiley Online Library
… tested in this study, six 25-mg tablets and one 150-mg tablet, are bioequivalent, so
plasma exposure and efficacy will not be affected if 25-mg tablets are substituted for a dose. …
plasma exposure and efficacy will not be affected if 25-mg tablets are substituted for a dose. …
Activity of erlotinib when dosed below the maximum tolerated dose for EGFR‐mutant lung cancer: Implications for targeted therapy development
BL Lampson, M Nishino, SE Dahlberg, D Paul… - Cancer, 2016 - Wiley Online Library
… On the basis of the in vitro data described above, we hypothesized that reduced-dose
erlotinib has similar efficacy to the MTD of erlotinib and represents a viable treatment option for …
erlotinib has similar efficacy to the MTD of erlotinib and represents a viable treatment option for …
Budget impact of erlotinib for maintenance therapy in advanced non-small cell lung cancer
… erlotinib maintenance therapy was given, the use of pemetrexed and docetaxel increased in
2nd-line therapy due to our assumption that patients would not be given erlotinib in … efficacy …
2nd-line therapy due to our assumption that patients would not be given erlotinib in … efficacy …
Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non–small-cell lung cancer: a phase III trial
GV Scagliotti, M Krzakowski, A Szczesna… - Journal of clinical …, 2012 - ascopubs.org
… be efficacious. Nonclinical evidence from NSCLC xenograft models suggests that sunitinib
increases the antitumor activity of erlotinib. … the efficacy and safety of sunitinib plus erlotinib in …
increases the antitumor activity of erlotinib. … the efficacy and safety of sunitinib plus erlotinib in …
[HTML][HTML] Efficacy and safety of anti-angiogenic drugs combined with erlotinib in the treatment of advanced non-small cell lung cancer: a meta-analysis of randomized …
Z Chen, S Jiang, X Li, J Zhang, L Liu… - Annals of Palliative …, 2021 - apm.amegroups.org
… explored the efficacy and safety of VEGF neutralizing antibodies, combined with erlotinib. …
was to explore the efficacy and safety of combined medications, and simultaneously to conduct …
was to explore the efficacy and safety of combined medications, and simultaneously to conduct …
Erlotinib in the treatment of recurrent or metastatic cutaneous squamous cell carcinoma: a single‐arm phase 2 clinical trial
KA Gold, MS Kies, WN William Jr, FM Johnson… - Cancer, 2018 - Wiley Online Library
… the closely related EGFR tyrosine kinase inhibitor erlotinib. Erlotinib 150 mg daily was more
… it was important to establish the efficacy of erlotinib monotherapy with a phase 2 single-arm …
… it was important to establish the efficacy of erlotinib monotherapy with a phase 2 single-arm …
Final survival and safety results from a multicenter, open‐label, phase 3b trial of erlotinib in patients with advanced nonsmall cell lung cancer
DR Spigel, M Lin, V O'Neill… - … International Journal of …, 2008 - Wiley Online Library
… Erlotinib is an … of erlotinib in patients with advanced NSCLC who had progressed after
standard chemotherapy treatment was conducted to examine the efficacy and safety of erlotinib …
standard chemotherapy treatment was conducted to examine the efficacy and safety of erlotinib …
Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double …
… Bevacizumab and erlotinib target different tumour growth … of erlotinib plus bevacizumab
for recurrent or refractory non-small-cell lung cancer (NSCLC), we aimed to assess efficacy and …
for recurrent or refractory non-small-cell lung cancer (NSCLC), we aimed to assess efficacy and …
[HTML][HTML] A randomized phase II study comparing erlotinib versus erlotinib with alternating chemotherapy in relapsed non-small-cell lung cancer patients: the NVALT-10 …
JG Aerts, H Codrington, NAG Lankheet, S Burgers… - Annals of oncology, 2013 - Elsevier
… or pemetrexed and intermitted erlotinib with single-agent erlotinib in second-line treatment
of NSCLC are available in the current literature. The increased efficacy of combining these …
of NSCLC are available in the current literature. The increased efficacy of combining these …