Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer

DJ Stewart - Critical reviews in oncology/hematology, 2010 - Elsevier
cell cycling or transcription factors. Factors for which there is now substantial clinical evidence
of a link to small cell lung cancer (… In non-small cell lung cancer (NSCLC), the strongest …

[HTML][HTML] Predictors of chemotherapy efficacy in non-small-cell lung cancer: a challenging landscape

KA Olaussen, S Postel-Vinay - Annals of Oncology, 2016 - Elsevier
… Conventional cytotoxic chemotherapy (CCC) is the backbone of non-small-cell lung cancer
(NSCLC) treatment since decades and still represents a key element of the therapeutic …

Immunotherapeutic approaches for small-cell lung cancer

WT Iams, J Porter, L Horn - Nature Reviews Clinical Oncology, 2020 - nature.com
… In this Review, we describe the available data on clinical efficacy, the emerging evidence
regarding biomarkers and ongoing clinical trials using ICIs and other immunotherapies in …

[PDF][PDF] Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: a phase II study.

RP Abratt, WR Bezwoda, G Falkson… - Journal of Clinical …, 1994 - researchgate.net
… Purpose: The aim of this study was to evaluate the efficacy and toxicity of gemcitabine at
higher doses than had been used previously in patients with non-smallcell lung cancer (NSCLC)…

SUNSET: Stereotactic radiation for ultracentral non–small-cell lung cancer—A safety and efficacy trial

M Giuliani, AS Mathew, H Bahig, SV Bratman, E Filion… - Clinical lung cancer, 2018 - Elsevier
Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment
for medically inoperable early stage non–small-cell lung cancer (… objective of the study is to …

[HTML][HTML] Erlotinib in advanced non-small cell lung cancer: efficacy and safety findings of the global phase IV Tarceva Lung Cancer Survival Treatment study

M Reck, N van Zandwijk, C Gridelli, Z Baliko… - Journal of Thoracic …, 2010 - Elsevier
… advanced non-small cell lung cancer. Here, we report safety and efficacy data from a
large, global, open-label, phase IV trial of erlotinib (Tarceva Lung Cancer Survival Treatment). …

Navitoclax enhances the efficacy of taxanes in non–small cell lung cancer models

N Tan, M Malek, J Zha, P Yue, R Kassees, L Berry… - … Cancer Research, 2011 - AACR
… time from mitotic arrest to cell death and therefore may increase the window of time when
taxanes are efficacious. We also show that non–small cell lung cancer (NSCLC) models with …

[PDF][PDF] Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non–small-cell lung cancer

G Simon, A Sharma, X Li, T Hazelton… - Journal of Clinical …, 2007 - researchgate.net
… -cell lung cancer (NSCLC) is based on clinical trials experience. Molecular characteristics that
impact metabolism and efficacy … determinant of gemcitabine efficacy. Excision repair cross-…

Efficacy of Tumor Vaccines and Cellular Immunotherapies in Non–Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

F Dammeijer, LA Lievense, GDM Veerman… - Journal of Clinical …, 2016 - ascopubs.org
… the efficacy of tumor vaccination and … Lung cancer is the leading cause of cancer-related
mortality worldwide. Non–small-cell lung cancer (NSCLC) comprises 85% of all lung cancers

Combination epigenetic therapy has efficacy in patients with refractory advanced non–small cell lung cancer

RA Juergens, J Wrangle, FP Vendetti, SC Murphy… - Cancer discovery, 2011 - AACR
… in this study. Second primary cancers are common in patients with lung cancer and are
associated with similar carcinogenic exposure throughout the lung field (34). Although it is …