… alterations in a precise and efficient manner is base editing. Base editing is unique in that
it … in the process of genome and transcriptome editing (Figs 1 and 2). Both DNA and RNA …

… First, we carried out base editing in mouse embryos by microinjection of BE3-encoding …
: Dystrophin-deficient mutant mice generated by cytidine-deaminase-mediated base editing. …

… Their high editing efficiency, coupled with their ability to … DNA template, suggests that DNA
base editors will be useful for … DNA base editor shortcomings, including off-target DNA editing, …

… Thus, a deaminase that can catalyse nucleobase deamination in dsDNA is required for
efficient base editing in organellar DNA. DddA is an interbacterial toxin identified in Burkholderia …

… Yet, the efficiency and specificity of base editors has not been demonstrated in human embryos.
Here, we report that both base editor 3 (… efficiently in human tripronuclear (3PN) zygotes. …

… In this study, we test the multiplexed base editing efficiency of BE3 (rAPOBEC1-XTEN-… base
editing efficiently in embryonic and cellular levels. We also realize multiple copy base editing …

… -to-T base editing by current BEs and develop BEs for efficient C-to-T base editing in highly
methylated regions. Figure 1: hA3A-BE3 induces efficient base editing in a methylated region …

… Overall, we firstly demonstrate that base editors (both CBEs and ABEs) provide a simple
and highly efficient method for inducing single-nucleotide substitution in rabbit. …

… sequence editing window and is inefficient in GC contexts. Here, we show that a base
editor … PBE) converts cytidine to thymidine efficiently in wheat, rice and potato with a 17-nucleotide …

… Base editors directly convert one base or base pair into another, enabling the … BE2 mediates
efficient base editing in bacterial cells 54 and moderately efficient editing in mammalian cells…