… base to identify lung cancer patients who might benefit from EGFR-specific antibodies, we
studied the relationship between EGFR-expression on protein level and gene copy numbers …

… used IHC test for EGFR, and this was the clinical trial assay in the BR21 study that led to
the market authorization of erlotinib. We also analyzed gene copy number by FISH using the …

… Increased HER2/Neu gene copy number has … EGFR copy number, EGFR overexpression
or EGFR mutation [14]. Other studies have shown that tumours co-expressing HER2 and EGFR …

… copy number variants (CNVs) on the efficacy of tyrosine kinase inhibitors (TKIs) in EGFR-mutated
non-small cell lung cancer (… (PFS) and overall survival (OS) in EGFR wild-type patients. …

… progression of early stage lung adenocarcinoma, especially in conjunction with EGFR/RAS/…
prognostic factor in stage I adenocarcinoma subgroup, as well as in EGFR-mutant subgroup. …

… histology type, the distribution of high EGFR copy numbers is mostly independent of … EGFR
copy number might be a good candidate marker for high sensitivity to EGFR-TKIs in EGFR …

… association of EGFR overexpression in lung cancer, however… study of EGFR gene copy
number in lung carcinomas using … to EGFR gene and chromosome 7 copy numbers present per …

… In conclusion, this study showed that, independently of the method for EGFR assessment,
increased copy numbers of the HER2 gene enhance sensitivity to gefitinib therapy in NSCLC …

… the idea that EGFR copy number is a biomarker for response to EGFR-TKI therapy in patients
with advanced NSCLC, and could be used as an accurate predictor of EGFR-TKI response …

… gene copy number and protein expression for MET and EGFR in NSCLC patients. … be
analysed in the context of EGFR copy number status and clinicopathological variables in NSCLC. …