… Importantly, MCL-1 can be targeted pharmaceutically to improve responses. This study
supports the use of MCL-1 inhibitors in combination with EGFR inhibitors to eliminate EGFR-…

… of EGFR, accompanied with Mcl-1 reduction in … direct inhibition of Mcl-1 with an Mcl-1 inhibitor
in combination with osimertinib exerts enhanced effect on decreasing the survival of EGFR …

… induced apoptosis in EGFR-mutant … Mcl-1 reduction likely due to enhanced Mcl-1 degradation
and increased Bim stability. Blocking Bim elevation by gene knockdown or enforcing Mcl-1 …

… to irreversible EGFR-TKIs linking glucose metabolism to Mcl-1 … inhibitor of glucose
metabolism with irreversible EGFR-TKIs in the treatment of NSCLCs with secondary EGFR …

… To that end, we now demonstrate that EGFR regulates Bim:Mcl - 1 interactions to promote
Mcl - 1 dependence in HR NBs and that successful small molecule inhibition of EGFR or its …

… Mcl-1 levels.As shown in Figure 6A, inhibition of EGFR has no effect on expression of Mcl-1 …
effect of these EGFR inhibitors on constitutive Stat3 activity and apoptosis in these cells.…

… Overall, this study demonstrated that Formo acts as an inhibitor for the EGFR-Akt axis, and
promotes FBW7-mediated Mcl-1 ubiquitination is required for the anti-tumor activity of Formo …

… involvement of EGFR signaling in the Notch1-dependent regulation of Mcl-1, we transiently
overexpressed EGFR after Notch1 knockdown. As expected, this rescued the Mcl-1 protein …

… To identify additional ubiquitin ligases or deubiquitinases (DUB) that may regulate MCL1
degradation in response to EGFR inhibition, we carried out large-scale immunopurifications of …

… or tertiary EGFR mutations and other mechanisms [52]. After exposure to EGFR inhibitors,
EGFR-… of MCL-1 and finally become “drug-tolerant cells.” This overexpression is explained by (…