… of morpholine together with 2-(p-Cl phenyl) and 6–(2-furyl) 20f afforded the most potent
EGFR inhibitors in this study displaying IC 50 range from 20.15 ± 1.07 to 25.39 ± 3.49 nM. …

… as well as PARP-1 inhibition. QSAR analysis and molecular modelling studies were carried
… representing the binding modes of the promising compounds in the active pocket of EGFR. …

… , antioxidant, and EGFR kinase inhibition activities of the designed molecules (G; Figure 1 )
… subjected to EGFR kinase inhibition test and docked into the binding sites of EGFR kinase …

… data that dual inhibition of EGFR/… inhibitors [19,39,40,41,42] and EGFR inhibitors 1M17
[43,44], the present study was designed for synthesis of novel dual EGFR/HDAC hybrid inhibitors …

… EGFR T790M+C797S mutant TK allosteric inhibitors from the ZINC database. The screening
comprised XP molecular docking of 3,92,945 compounds into the allosteric site of EGFR …

… their role in inhibiting EGFR. Hence, in the present research we have taken EGFR inhibitors
which are in various phases of clinical trials and a ligand-based pharmacophore model was …

… In the molecular modelling study, compound 9i was bound in to the active pocket of EGFR
with four hydrogen bonds and two π–cation interactions having minimum binding energy ΔG b …

… model has been developed using diverse classes of epidermal growth factor receptor (EGFR)
tyrosine kinase (TK) inhibitors … The model also maps well to the external test set molecules …

… as reference selective EGFR and HER2 kinase inhibitors respectively [25,… EGFR/HER2
kinase inhibitors in this study with IC 50 values of 0.153 (EGFR), 0.108 (HER2), and 0.122 (EGFR)…

… between the inhibitor molecules and the … models that we constructed for molecular docking
studies to rationally design compounds predicted to bind favorably to the modeled EGFR …