… cell lung cancer and the subsequent discovery of activating EGFR mutations have led to an
… of knowledge in the fields of EGFR biology, targeted therapeutics and lung cancer research. …

… that lung cancers harboring constitutively active mutant EGFR are exquisitely sensitive to
the apoptotic or growth inhibitory activities of EGFR … mutations in carcinogenesis and cancer …

… with metastatic EGFR exon19del or L858R-mutant lung cancers treated with first/second-generation
EGFR … EGFR wild-type lung adenocarcinoma samples were used for comparison. …

… The test also detects the T790M mutation associated with resistance to tyrosine kinase …
non–small-cell lung cancers previously identified as having the EGFR mutation and 8 specimens …

… In addition, detecting T790M may be useful for predicting pretreatment resistance to EGFR
… role of EGFR mutations in the development of EGFR-related non–small-cell lung cancer and …

… B, Mechanisms of acquired resistance to EGFR TKIs in EGFR mutated non-small-cell lung
cancer (NSCLC) with emphasis on the EGFR-T790M resistant mutation and oncogene bypass …

… lung cancers with somatic EGFR mutations and that prospective clinical trials of EGFR inhibition
in patients with EGFR mutations … Identification of EGFR mutations in other malignancies, …

… of 1,122 EGFR-mutant lung cancer cell-free … EGFR-mutant lung cancer, we identified critical
co-occurring oncogenic events present in most advanced-stage EGFR-mutant lung cancers. …

… Histologic transformation into small cell lung cancer (SCLC) has been reported in up to 14%
of EGFR-mutant lung cancers at disease progression after first-generation EGFR TKIs 28 . A …

… (EGFR) provide important insights for new lung cancer therapies, as well as for the broader
field of targeted cancer … studies focused on somatic mutations of EGFR that are associated …