… refute the role of EGFR mutations as predictive factors, because EGFR mutations failed
only to significantly affect overall survival (P = 0.09), while EGFR mutations were predictive of …

… We review the role of EGFR mutations in the diagnosis and … current knowledge of EGFR TK
domain mutations and the role … of EGFR mutation status in the selection of patients for EGFR …

… ment of tyrosine kinase inhibitors (TKIs) of EGFR have achieved a paradigm shift in … cell
lung cancer (NSCLC). For advanced NSCLC harboring activating EGFR mutations, an EGFR-TKI …

… We performed EGFR mutational analysis on DNA recovered from circulating … the EGFR
mutations detected in circulating tumor cells by SARMS with those reported for the tumor …

… a patient with EGFR-mutant, gefitinib-responsive, advanced non–small-cell lung cancer who
… The DNA sequence of the EGFR gene in his tumor biopsy specimen at relapse revealed the …

… whose tumors harbor EGFR mutations, 20 in this study 72% of patients overall and 70% of
T790M-positive patients who had a response were also taking an EGFR inhibitor immediately …

… the oncogenic potential of mutated EGFR: they created … EGFR mutants seen in human lung
cancer. Both transgenic lines developed lung adenocarcinoma after sustained mutant EGFR …

… lung cancers with somatic EGFR mutations and that prospective clinical trials of EGFR inhibition
in patients with EGFR mutations … Identification of EGFR mutations in other malignancies, …

… The discovery of EGFR tyrosine kinase inhibitors (TKI) was regarded as a landmark finding
… of lung cancer [5–8]. Targeted EGFR-TKI first-line treatment of sensitizing EGFR mutations …

… -cell lung cancers for EGFR mutations have been negative. Thus, small-cell lung cancers are
not routinely tested for EGFR mutations… responsiveness to EGFR tyrosine kinase inhibitors. …