… We review the role of EGFR mutations in the diagnosis and … current knowledge of EGFR TK
domain mutations and the role … of EGFR mutation status in the selection of patients for EGFR …

… cell lung cancer and the subsequent discovery of activating EGFR mutations have led to an
… of knowledge in the fields of EGFR biology, targeted therapeutics and lung cancer research. …

… A recent report exploring the sensitivity of uncommon EGFR mutations to … EGFR mutations,
namely point mutations in position Gly719 of exon 18 (G719) and Leu861Gln mutation in …

… to EGFR-TKIs. We also discuss from our studies the relationship between EGFR mutations
… the mechanism of the pathogenesis of lung cancer. The accumulated important data confer …

… a patient with EGFR-mutant, gefitinib-responsive, advanced non–small-cell lung cancer who
… The DNA sequence of the EGFR gene in his tumor biopsy specimen at relapse revealed the …

… ment of tyrosine kinase inhibitors (TKIs) of EGFR have achieved a paradigm shift in … cell
lung cancer (NSCLC). For advanced NSCLC harboring activating EGFR mutations, an EGFR-TKI …

… lung cancers with somatic EGFR mutations and that prospective clinical trials of EGFR inhibition
in patients with EGFR mutations … Identification of EGFR mutations in other malignancies, …

… The discovery of EGFR tyrosine kinase inhibitors (TKI) was regarded as a landmark finding
… of lung cancer [5–8]. Targeted EGFR-TKI first-line treatment of sensitizing EGFR mutations …

… with metastatic EGFR exon19del or L858R-mutant lung cancers treated with first/second-generation
EGFR … EGFR wild-type lung adenocarcinoma samples were used for comparison. …

… EGFR mutations, not all cases with such mutations demonstrate a potent drug response. To
address the predictive value of EGFR mutations, … in 46% of EGFR mutant NSCLC, compared …