Association of pharmacokinetics and pharmacogenomics with safety and efficacy of gefitinib in patients with EGFR mutation positive advanced non-small cell lung …
T Hirose, K Fujita, S Kusumoto, Y Oki, Y Murata… - Lung Cancer, 2016 - Elsevier
… a correlation between pharmacokinetics and pharmacogenomics of another EGFR-… EGFR
mutation-positive advanced NSCLC, the pharmacokinetics of gefitinib and pharmacogenomics …
mutation-positive advanced NSCLC, the pharmacokinetics of gefitinib and pharmacogenomics …
Pharmacogenomics, pharmacokinetics, and pharmacodynamics in the era of targeted therapies
… pharmacogenomics, pharmacokinetics, and pharmacodynamics among patients with cancer.
… of these EGFR-activating mutations occur in exons 18 to 21 and predict response to EGFR …
… of these EGFR-activating mutations occur in exons 18 to 21 and predict response to EGFR …
Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese …
M Fukudo, Y Ikemi, Y Togashi, K Masago… - … pharmacokinetics, 2013 - Springer
… wild-type patients while having less of an impact on the tumor response in EGFR mutation-…
population pharmacokinetics and pharmacogenomics of erlotinib and its pharmacokinetic and …
population pharmacokinetics and pharmacogenomics of erlotinib and its pharmacokinetic and …
Pharmacogenomics of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
… of this report is that egfr mutations were never found along with Kras mutations, and were …
placebo 177 samples were analyzed for egfr mutations, and a mutation incidence of 22% was …
placebo 177 samples were analyzed for egfr mutations, and a mutation incidence of 22% was …
A safety, pharmacokinetic, pharmacogenomic and population pharmacokinetic analysis of the third‐generation EGFR TKI, olmutinib (HM61713), after single oral …
YS Noh, S Yoon, SR Kim, KT Lee… - Basic & Clinical …, 2019 - Wiley Online Library
… pharmacokinetics (PKs) of olmutinib in three racial subjects. We also evaluate safety/tolerability
and a population PK and pharmacogenomic … Pharmacogenomic analysis indicated that …
and a population PK and pharmacogenomic … Pharmacogenomic analysis indicated that …
[HTML][HTML] Pharmacokinetic and pharmacogenomic analysis of low-dose afatinib treatment in elderly patients with EGFR mutation-positive non–small cell lung cancer
H Mizugaki, S Oizumi, Y Fujita, T Harada… - European Journal of …, 2022 - Elsevier
… for low-dose afatinib (30 mg/day) use in elderly patients with NSCLC with EGFR mutation to
assess quality-of-life (QOL) and pharmacokinetic (PK)/pharmacogenomic (PGx) parameters. …
assess quality-of-life (QOL) and pharmacokinetic (PK)/pharmacogenomic (PGx) parameters. …
Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity
CM Rudin, W Liu, A Desai, T Karrison… - Journal of Clinical …, 2008 - ascopubs.org
… a major effect on drug pharmacokinetics and pharmacodynamics. EGFR, encoding the direct
… An intronic microsatellite polymorphism has been associated with EGFR expression, with …
… An intronic microsatellite polymorphism has been associated with EGFR expression, with …
[HTML][HTML] Association of Pharmacokinetics or Pharmacogenomics with Toxicity of Erlotinib in Patients with Recurrent Advanced Non-Small Cell Lung Cancer
T Hirose, K Fujita, S Kusumoto, Y Oki, Y Murata… - Annals of …, 2014 - Elsevier
… cancer (NSCLC) harboring EGFR mutation. The orally administered … pharmacokinetics.
The aim of this study was to evaluate the association of pharmacokinetics or pharmacogenomics …
The aim of this study was to evaluate the association of pharmacokinetics or pharmacogenomics …
Practical recommendations for pharmacogenomics-based prescription: 2010 ESF–UB Conference on Pharmacogenetics and Pharmacogenomics
L Becquemont, A Alfirevic, U Amstutz, H Brauch… - …, 2011 - Taylor & Francis
… /pharmacogenomic label for these EGFR antibodies indicating that tumors with KRAS
mutations … A population pharmacokinetic–pharmacogenetic model of tacrolimus was presented …
mutations … A population pharmacokinetic–pharmacogenetic model of tacrolimus was presented …
[HTML][HTML] Integration of liquid biopsy and pharmacogenomics for precision therapy of EGFR mutant and resistant lung cancers
… growth factor receptor (EGFR) gene. Drug resistance caused by EGFR mutations and genetic
… and transporters impedes effective treatment of EGFR mutant and resistant lung cancer. …
… and transporters impedes effective treatment of EGFR mutant and resistant lung cancer. …
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