… The development and clinical application of inhibitors that target the epidermal growth factor
receptor (EGFR) provide important insights for new lung cancer therapies, as well as for the …

… panel of EGFR mutations reported in NSCLC patients. In addition, we analyzed the
sensitivity of EGFR mutations toward the EGFR inhibitors gefitinib, erlotinib, and AEE788. …

… EGFR mutations in patients, our understanding of the biology of these … EGFR mutations is
poor compared to classical mutations. In particular, clinical data focused on these mutations is …

… Mutation in the tyrosine kinase domain of the EGFR gene … with an EGFR mutation are highly
sensitive to EGFR tyrosine … EGFR, the EGFR signal transduction pathway and mutations …

… 134 epidermal growth factor receptor (EGFR) gene mutations detected in lung cancers. The
structure of the EGFR gene is shown at left, and the locations and types of the mutations in …

… of epidermal growth factor receptor (EGFR)gene mutations have been … EGFR amplification.
The objectives of this study were to determine the frequency and diversity of EGFR mutations …

… activating mutations in the epidermal growth factor receptor (EGFR… Patients with EGFR
mutations were considered for … evaluated the association between EGFR mutations and outcome. …

… Mutations in epidermal growth factor receptor have been … Lung adenocarcinomas with
mutated epidermal growth factor … Both EGFR mutation and gene amplification status may be …

… , including epidermal growth factor receptor (EGFR) gene mutations. … EGFR mutated NSCLC
and EGFR tyrosine kinase inhibitors (TKIs). Classic somatic EGFR kinase domain mutations …

… Amplification of the EGFR gene and mutations of the EGFR tyrosine kinase domain have
been recently demonstrated to occur in carcinoma patients. Interestingly, both these genetic …