Epidermal growth factor receptor mutations in lung cancer
SV Sharma, DW Bell, J Settleman, DA Haber - Nature Reviews Cancer, 2007 - nature.com
… The development and clinical application of inhibitors that target the epidermal growth factor
receptor (EGFR) provide important insights for new lung cancer therapies, as well as for the …
receptor (EGFR) provide important insights for new lung cancer therapies, as well as for the …
Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy
RK Kancha, N Von Bubnoff, C Peschel, J Duyster - Clinical cancer research, 2009 - AACR
… panel of EGFR mutations reported in NSCLC patients. In addition, we analyzed the
sensitivity of EGFR mutations toward the EGFR inhibitors gefitinib, erlotinib, and AEE788. …
sensitivity of EGFR mutations toward the EGFR inhibitors gefitinib, erlotinib, and AEE788. …
[HTML][HTML] Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer
… EGFR mutations in patients, our understanding of the biology of these … EGFR mutations is
poor compared to classical mutations. In particular, clinical data focused on these mutations is …
poor compared to classical mutations. In particular, clinical data focused on these mutations is …
Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer
T Mitsudomi, Y Yatabe - The FEBS journal, 2010 - Wiley Online Library
… Mutation in the tyrosine kinase domain of the EGFR gene … with an EGFR mutation are highly
sensitive to EGFR tyrosine … EGFR, the EGFR signal transduction pathway and mutations …
sensitive to EGFR tyrosine … EGFR, the EGFR signal transduction pathway and mutations …
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
H Shigematsu, L Lin, T Takahashi… - Journal of the …, 2005 - academic.oup.com
… 134 epidermal growth factor receptor (EGFR) gene mutations detected in lung cancers. The
structure of the EGFR gene is shown at left, and the locations and types of the mutations in …
structure of the EGFR gene is shown at left, and the locations and types of the mutations in …
Diversity and Frequency of Epidermal Growth Factor Receptor Mutations in Human Glioblastomas
L Frederick, XY Wang, G Eley, CD James - Cancer research, 2000 - AACR
… of epidermal growth factor receptor (EGFR)gene mutations have been … EGFR amplification.
The objectives of this study were to determine the frequency and diversity of EGFR mutations …
The objectives of this study were to determine the frequency and diversity of EGFR mutations …
Screening for epidermal growth factor receptor mutations in lung cancer
… activating mutations in the epidermal growth factor receptor (EGFR… Patients with EGFR
mutations were considered for … evaluated the association between EGFR mutations and outcome. …
mutations were considered for … evaluated the association between EGFR mutations and outcome. …
[HTML][HTML] Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update
G Bethune, D Bethune, N Ridgway… - Journal of thoracic …, 2010 - ncbi.nlm.nih.gov
… Mutations in epidermal growth factor receptor have been … Lung adenocarcinomas with
mutated epidermal growth factor … Both EGFR mutation and gene amplification status may be …
mutated epidermal growth factor … Both EGFR mutation and gene amplification status may be …
[HTML][HTML] Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data
… , including epidermal growth factor receptor (EGFR) gene mutations. … EGFR mutated NSCLC
and EGFR tyrosine kinase inhibitors (TKIs). Classic somatic EGFR kinase domain mutations …
and EGFR tyrosine kinase inhibitors (TKIs). Classic somatic EGFR kinase domain mutations …
Epidermal growth factor receptor (EGFR) signaling in cancer
N Normanno, A De Luca, C Bianco, L Strizzi… - Gene, 2006 - Elsevier
… Amplification of the EGFR gene and mutations of the EGFR tyrosine kinase domain have
been recently demonstrated to occur in carcinoma patients. Interestingly, both these genetic …
been recently demonstrated to occur in carcinoma patients. Interestingly, both these genetic …
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