EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

JG Paez, PA Janne, JC Lee, S Tracy, H Greulich… - Science, 2004 - science.org
… Treatment with the EGFR kinase … EGFR mutations were found in additional lung cancer
samples from US patients who responded to gefitinib therapy and in a lung adenocarcinoma cell …

Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma

H Makinoshima, M Takita, S Matsumoto… - Journal of Biological …, 2014 - ASBMB
… We initially characterized the EGFR-mutated lung adenocarcinoma cell lines used in this …
or presence of EGFR-TKIs after 72 h. All three LAD cell lines have the EGFR mutation in either …

[HTML][HTML] EGFR mutation incidence in non-small-cell lung cancer of adenocarcinoma histology: a systematic review and global map by ethnicity (mutMapII)

A Midha, S Dearden, R McCormack - American journal of cancer …, 2015 - ncbi.nlm.nih.gov
… describe the EGFR mutation frequency in patients with NSCLC/ADC from multiple ethnic
backgrounds and create a global map of EGFR mutation prevalence (a ‘global EGFR mutMap’). …

Screening for EGFR mutations in lung cancer, a report from India

R Sahoo, VC Babu, GVP Okaly, S Rao, A Nargund… - Lung cancer, 2011 - Elsevier
… In conclusion, screening for EGFR mutation is warranted in women with lung cancer, in …
EGFR mutation is feasible using FNAC/core needle biopsy sample. Statistics of EGFR mutation

Small cell lung cancer transformation from EGFR-mutated lung adenocarcinoma: a case report and literatures review

Y Liu - Cancer biology & therapy, 2018 - Taylor & Francis
… to EGFR-TKIs. The transformation of lung adenocarcinoma to small cell lung cancer (SCLC)
following treatment with EGFR-TKIs is rare, which leads to resistance to EGFR-TKIs. …

A comprehensive review of uncommon EGFR mutations in patients with non-small cell lung cancer

HY Tu, EE Ke, JJ Yang, YL Sun, HH Yan, MY Zheng… - Lung Cancer, 2017 - Elsevier
… of uncommon EGFR mutation in Chinese lung cancer patients and their sensitivity to
EGFR-TKIs. Patients with uncommon EGFR mutations demonstrated diverse responses to EGFR-…

Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study

HY Yoon, JS Ryu, YS Sim, D Kim, SY Lee, J Choi… - PLoS …, 2020 - journals.plos.org
mutation. In conclusion, the presence of EGFR mutations in advanced lung adenocarcinoma
… prognosis than other mutations, while an E21 mutation is expected to increase mortality. …

[HTML][HTML] Distinct epidemiology and clinical consequence of classic versus rare EGFR mutations in lung adenocarcinoma

Z Lohinai, MA Hoda, K Fabian, G Ostoros… - Journal of thoracic …, 2015 - Elsevier
… On the basis of the COSMIC database (retrieved at July 28, 2014), we found synonymous
and rare EGFR gene mutations already published in lung cancer (N = 33 mutations) or in …

[HTML][HTML] A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non–small-cell lung cancer of adenocarcinoma histology …

Y Shi, JSK Au, S Thongprasert, S Srinivasan… - Journal of thoracic …, 2014 - Elsevier
… PIONEER is the first prospective study to confirm high EGFR mutation frequency (51.4%
overall) in tumors from Asian patients with adenocarcinoma. The observed high mutation

[HTML][HTML] Uncommon EGFR mutations in lung adenocarcinoma: features and response to tyrosine kinase inhibitors

A Brindel, W Althakfi, M Barritault, E Watkin… - Journal of Thoracic …, 2020 - ncbi.nlm.nih.gov
… the results of a large study of patients with lung adenocarcinoma genotyped for EGFR
mutations; the data describe the frequency and the prognosis of uncommon EGFR mutations. …