… EGFR‑mutated non‑small cell lung cancer (NSCLC). Due to the relatively high frequency of
EGFR mutation in patients with lung adenocarcinoma … number of patients develop EGFR‑TKI …

… We identified the expected EGFR activating mutation in circulating tumor … mutation, which
confers drug resistance, in circulating tumor cells collected from patients with EGFR mutations …

… PIONEER is the first prospective study to confirm high EGFR mutation frequency (51.4%
overall) in tumors from Asian patients with adenocarcinoma. The observed high mutation …

… EGFR mutations account for 10–18% of all EGFR mutations and primarily consist of exon 20
insertions, exon 18 point mutations and complex mutations… uncommon EGFR mutations and …

… the results of a large study of patients with lung adenocarcinoma genotyped for EGFR
mutations; the data describe the frequency and the prognosis of uncommon EGFR mutations. …

… the tyrosine kinase of EGFR, which competitively inhibits ATP-… lung adenocarcinoma with
EGFRmutations (overall response rate [ORR], 71.2%), but not for that without EGFR-mutations (…

… mutation. In conclusion, the presence of EGFR mutations in advanced lung adenocarcinoma
… prognosis than other mutations, while an E21 mutation is expected to increase mortality. …

… of lung adenocarcinomas with EGFR mutations from 436 … mutations and 64 tumors (14%)
with compound mutations. The single-mutation tumors included 362 (78%) common mutations (…

… the oncogenic potential of mutated EGFR: they created … EGFR mutants seen in human lung
cancer. Both transgenic lines developed lung adenocarcinoma after sustained mutant EGFR …

… We found a significant association between EGFR mutation and risk of brain metastases …
pulmonary adenocarcinoma. This result indicates the distinct clinical features of EGFR-mutated …