[HTML][HTML] EGFR-mutated lung cancer: a paradigm of molecular oncology
… cell lung cancer and the subsequent discovery of activating EGFR mutations have led to an
… of knowledge in the fields of EGFR biology, targeted therapeutics and lung cancer research. …
… of knowledge in the fields of EGFR biology, targeted therapeutics and lung cancer research. …
EGFR mutations and lung cancer
G da Cunha Santos, FA Shepherd… - Annual Review of …, 2011 - annualreviews.org
… EGFR TKIs. This review summarizes the current knowledge of EGFR TK domain mutations
and … the importance of EGFR mutation status in the selection of patients for EGFR TKI therapy. …
and … the importance of EGFR mutation status in the selection of patients for EGFR TKI therapy. …
Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
… lung cancer (median number, 74 cells per milliliter). We identified the expected EGFR activating
mutation … We detected the T790M mutation, which confers drug resistance, in circulating …
mutation … We detected the T790M mutation, which confers drug resistance, in circulating …
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
JG Paez, PA Janne, JC Lee, S Tracy, H Greulich… - Science, 2004 - science.org
… lung cancers with somatic EGFR mutations and that prospective clinical trials of EGFR inhibition
in patients with EGFR mutations … Identification of EGFR mutations in other malignancies, …
in patients with EGFR mutations … Identification of EGFR mutations in other malignancies, …
Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors
DA Haber, DW Bell, R Sordella… - Cold Spring Harbor …, 2005 - symposium.cshlp.org
… to gefitinib or erlotinib harbor EGFR mutations, not all cases with such mutations demonstrate
a potent drug response. To address the predictive value of EGFR mutations, we analyzed …
a potent drug response. To address the predictive value of EGFR mutations, we analyzed …
Worldwide Frequency of Commonly Detected EGFR Mutations
RP Graham, AL Treece, NI Lindeman… - … of pathology & …, 2018 - meridian.allenpress.com
… to EGFR inhibitor therapies. Initial data have indicated an increased frequency of activating
EGFR mutations in … the question of mutation distribution across the population of lung cancer. …
EGFR mutations in … the question of mutation distribution across the population of lung cancer. …
EGFR mutation and response of lung cancer to gefitinib
S Toyooka, K Kiura, T Mitsudomi - N Engl J Med, 2005 - researchgate.net
… In addition, detecting T790M may be useful for predicting pretreatment resistance to EGFR
… role of EGFR mutations in the development of EGFR-related non–small-cell lung cancer and …
… role of EGFR mutations in the development of EGFR-related non–small-cell lung cancer and …
Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data
… B, Mechanisms of acquired resistance to EGFR TKIs in EGFR mutated non-small-cell lung
cancer (NSCLC) with emphasis on the EGFR-T790M resistant mutation and oncogene bypass …
cancer (NSCLC) with emphasis on the EGFR-T790M resistant mutation and oncogene bypass …
A comprehensive review of uncommon EGFR mutations in patients with non-small cell lung cancer
HY Tu, EE Ke, JJ Yang, YL Sun, HH Yan, MY Zheng… - Lung Cancer, 2017 - Elsevier
… This study reviewed the prevalence of uncommon EGFR mutations and their sensitivity to
EGFR… L858R mutations, indicating that they may benefit from EGFR-TKIs as a first-line therapy. …
EGFR… L858R mutations, indicating that they may benefit from EGFR-TKIs as a first-line therapy. …
Impact of EGFR mutation analysis in non-small cell lung cancer
H Yamamoto, S Toyooka, T Mitsudomi - Lung cancer, 2009 - Elsevier
… , because EGFR mutations are … of lung cancer, survival of patients with EGFR mutations
tends to be longer in those who undergo surgery only. To determine whether EGFR mutations …
tends to be longer in those who undergo surgery only. To determine whether EGFR mutations …
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