… therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase …

T Seto, T Kato, M Nishio, K Goto, S Atagi… - The lancet …, 2014 - thelancet.com
… However, this analysis was post-hoc and EGFR mutation status was not a … this phase 2
trial to examine the combination of erlotinib and bevacizumab in patients with EGFR mutation-…

… -cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, phase 3 …

S Lu, L Wu, H Jian, Y Chen, Q Wang, J Fang… - The Lancet …, 2022 - thelancet.com
… Although multiple high-quality randomised phase 3 trials have shown that immunotherapy
improves outcomes for patients with advanced NSCLC, those with EGFR mutations were …

[HTML][HTML] A prospective, multicentre phase II trial of low-dose erlotinib in non-small cell lung cancer patients with EGFR mutations pretreated with chemotherapy …

K Yamada, H Aono, Y Hosomi, H Okamoto… - European Journal of …, 2015 - Elsevier
… This multicentre phase II trial was conducted to evaluate the efficacy and safety of low-dose
erlotinib in chemotherapy-pretreated patients with NSCLC harbouring EGFR mutations. …

Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan …

K Tamura, I Okamoto, T Kashii, S Negoro… - British journal of …, 2008 - nature.com
… We performed a multicentre phase II study examining the use of gefitinib for advanced
NSCLC in patients with EGFR mutations, prospectively recruiting patients at the time of genetic …

… mutation-positive advanced non-small-cell lung cancer: results from the dose escalation and dose expansion parts of a first-in-human, open-label, multicentre, phase …

MJ Ahn, JY Han, KH Lee, SW Kim, DW Kim… - The Lancet …, 2019 - thelancet.com
… , phase 1–2 study, in which we enrolled patients with advanced NSCLC harbouring activating
mutations of EGFR that had progressed after EGFRmutations were enrolled), and a phase

SELECT: A multicenter phase II trial of adjuvant erlotinib in resected early-stage EGFR mutation-positive NSCLC.

NA Pennell, JW Neal, JE Chaft, CG Azzoli, PA Janne… - 2014 - ascopubs.org
7514 Background: EGFR mutant NSCLC is exquisitely sensitive to EGFR tyrosine kinase
inhibitors (TKIs). Retrospective data suggests adjuvant TKIs may improve outcomes. This trial is …

… first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase …

R Rosell, E Carcereny, R Gervais… - The lancet …, 2012 - thelancet.com
… In our open-label, multicentre, randomised phase 3 trial we … diagnosis of stage IIIB (with
pleural effusion) or stage IV … activating EGFR mutations (exon 19 deletion or L858R mutation in …

… and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 …

R Rosell, U Dafni, E Felip… - The Lancet …, 2017 - thelancet.com
… BELIEF was an international, multicentre, single-arm, phasestage IIIB or stage IV lung
adenocarcinoma with a confirmed, activating EGFR mutation (exon 19 deletion or L858R mutation

Safety and efficacy of nazartinib (EGF816) in adults with EGFR-mutant non-small-cell lung carcinoma: a multicentre, open-label, phase 1 study

DSW Tan, NB Leighl, GJ Riely, JCH Yang… - The Lancet …, 2020 - thelancet.com
… , phase 1/2 study was conducted at nine academic medical centres located in Europe, Asia,
… and had stage IIIB–IV EGFR-mutant NSCLC (with varying statuses of EGFR mutation and …

Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC: a multicenter phase-II trial

T Jiang, P Wang, J Zhang, Y Zhao, J Zhou… - … and Targeted Therapy, 2021 - nature.com
… This study was a multicenter, open-label, phase-II clinical trial evaluating the safety and …
treatment of advanced NSCLC with EGFR-sensitive mutations after failure of EGFR-TKI therapy (…