Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21

JY Yu, SF Yu, SH Wang, H Bai, J Zhao, TT An… - … journal of cancer, 2016 - Springer
… In conclusion, for patients with advanced lung adenocarcinoma, the use of first-line EGFR-TKIs
in patients who harbored the EGFR 19 del might be associated with higher ORR and …

Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma

H Uramoto, H Shimokawa, T Hanagiri, M Kuwano… - Lung Cancer, 2011 - Elsevier
… (EGFR) gene in lung adenocarcinoma are associated with a dramatic clinical response to
EGFR-tyrosine kinase inhibitors (TKIs… a relapse after treatment with EGFR-TKIs, even when the …

[HTML][HTML] Five-year survival in EGFR-mutant metastatic lung adenocarcinoma treated with EGFR-TKIs

JJ Lin, S Cardarella, CA Lydon, SE Dahlberg… - Journal of Thoracic …, 2016 - Elsevier
… We identified 137 patients in whom EGFR-mutant metastatic lung adenocarcinoma
developed and who were treated with gefitinib or erlotinib within the study period. Table 1 …

[HTML][HTML] Mechanisms and management of 3rd‑generation EGFRTKI resistance in advanced non‑small cell lung cancer

J He, Z Huang, L Han, Y Gong… - … journal of oncology, 2021 - spandidos-publications.com
… growth factor receptor (EGFR)‑tyrosine kinase inhibitors (TKIs) is a … EGFR‑mutated non‑small
cell lung cancer (NSCLC), and substantially improves their prognosis. However, EGFR

EGFR TKI combination with immunotherapy in non-small cell lung cancer

MJ Ahn, JM Sun, SH Lee, JS Ahn… - Expert opinion on drug …, 2017 - Taylor & Francis
Lung cancer is a leading cause of cancer-related death worldwide, with non–small-cell lung
cancer (NSCLC) accounting for 80–85% of all lung … growth factor receptor (EGFR) gene are …

Which biomarker predicts benefit from EGFR-TKI treatment for patients with lung cancer?

H Uramoto, T Mitsudomi - British journal of cancer, 2007 - nature.com
… As has been described, EGFR-TKIs are not universally effective for lung cancer, but these …
Asian, nonsmoking female patients with adenocarcinomas with EGFR mutations. The different …

EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas

ZY Chen, WZ Zhong, XC Zhang, J Su, XN Yang… - The …, 2012 - academic.oup.com
… in the EGFR mutation status in paired samples of primary pulmonary adenocarcinoma and
… Our results may help to explain the phenomenon of mixed tumor responses to EGFR TKIs

Epithelial− mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma

H Uramoto, T Iwata, T Onitsuka, H Shimokawa… - Anticancer …, 2010 - ar.iiarjournals.org
EGFR) gene in lung adenocarcinoma are associated with a dramatic clinical response to
EGFR tyrosine kinase inhibitor (TKI… initial response to treatment with EGFR-TKI in such patients, …

Transformation to small-cell lung cancer following treatment with EGFR tyrosine kinase inhibitors in a patient with lung adenocarcinoma

S Watanabe, T Sone, T Matsui, K Yamamura, M Tani… - Lung cancer, 2013 - Elsevier
… with lung adenocarcinoma that transformed to SCLC after acquired resistance to EGFR TKI
… -old female non-smoker with lung adenocarcinoma that transformed to SCLC 2 years after …

Pooled safety analysis of EGFR-TKI treatment for EGFR mutation-positive non-small cell lung cancer

M Takeda, I Okamoto, K Nakagawa - Lung Cancer, 2015 - Elsevier
… factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) – … with EGFR mutation-positive
non-small cell lung cancer (NSCLC). Given the long-term exposure of such patients to EGFR-TKIs, …