… –mRNA network to illustrate underlying molecular mechanisms of how EGFR-TKI resistance
… We found that target DE-mRNAs were mainly enriched in pathways involved in EGFR-…

… in EGFR-TKI … network between mRNAs and ncRNAs in EGFR-TKI resistance of NSCLC are
incompletely known. We aimed to define a ceRNA regulatory network linking mRNAs and non…

… SHISA3 can restrain EGFR-TKI resistance in PC9/ER. Given these data, we aimed to construct
a ceRNA network of circRNA-miRNA-mRNA that was related to EGFR-TKI resistance by …

… (erlotinib, gefitinib)-sensitive cell lines and six derived EGFR-TKI-resistant cell lines. We
aimed to identify lncRNA–mRNA sub-networks associated with resistance to EGFR-TKIs and/or …

… No EGFR-mutated cell lines were included in the cell line panel, but we … of EGFR-mutant
lung cancer cell lines to FGFR TKIs and their lack of FGFR1 expression (6, 11). Of the 17 EGFR-…

… EGFR mutation status (52 mutated and 103 wild-type cases) to identify the complex
miRNA–mRNA regulatory network … –mRNA network present in EGFR-mutated lung …

… downregulated lncRNAs and mRNAs from our microarray. … Then, we generated a core network
using the top 100 lncRNA-TF … In the core network of lncRNA-TF pairs, E2F1 participates in …

… Intriguingly, by analyzing PARIS data, we found that 3′ UTR of YRDC mRNA forms a
double-stranded structure only in EGFR-TKI-sensitive cells (Figure S4B), which unwound in both …

… explore the candidate miRNAs affecting the mRNA expressions of these proteins. We …
shared by EGFR and the other TKRs, possibly leading to the resistance of EGFR TKIs, and some …

… Basically, the efficacy of these EGFR-TKIs is limited based … -generation EGFR-TKI that is
selective for sensitising EGFR … of transcripts through elimination of mRNA with a premature stop …