… driven by epidermal growth factor receptor (EGFR) mutations, the EGFR tyrosine kinase
inhibitors (EGFR-TKIs, eg., gefitinib and … However, patients eventually develop drug resistance. …

… start a battle against EGFR-TKI resistance. Challenging as it … the major mechanisms of
acquired resistance to EGFR-TKIs, … drugs in accordance with each mechanism, in the hope of …

… liquid biopsies of resistant patients reveal … in mechanisms of resistance to 3rd‑generation
EGFR‑TKIs in advanced NSCLC, and provides possible strategies to overcome this resistance. …

… Over the past 10 years, great strides have been made in defining the molecular mechanisms
of EGFR TKI resistance in an effort to design rational strategies to overcome this acquired …

… To attenuate the effects that EGFR pathways take on cancers, EGFR TKIs that bind the …
mechanism and summarize the existing bypass tracks contributing to TKI resistance via EGFR-…

… EGFR-TKIs resistance mechanisms in NSCLC models and patients published in peer-reviewed
scientific journals and listed in PubMed since the discovery of EGFR… EGFR TKIs requires …

… reported in the past few years include secondary mutation of the EGFR gene, amplification
… resistance. This review focuses on these mechanisms of acquired resistance to EGFR-TKIs …

… mechanisms which contribute towards EGFR TKI resistance in NSCLC. Several therapeutic
approaches to overcome TKI resistance … and third generation EGFR TKI inhibitors and cMET …

… of resistance to such TKI inevitably occurs. The identification of these resistances remains …
the literature about molecular mechanisms of EGFR-TKI resistance in EGFR-mutated NSCLC, …

… EGFR-TKIs, and numerous resistance mechanisms have … of new resistance mechanisms
in the context of EGFR T790M-… of resistance mechanisms to EGFR third-generation TKIs and …