… of mechanisms of acquired resistance to EGFR TKIs have … common mechanism is the
development of acquired EGFR … % of EGFR–mutant cases that acquired resistance to EGFR TKIs …

… of the mechanisms underlying acquired TKI resistance is an … the most prevalent cause of
EGFR-TKI resistance. MET amplification … to resistance, is also involved in the mechanisms of TKI …

… focuses on resistance to EGFR TKIs, treatment strategies with EGFR-targeted monoclonal
antibodies may have to overcome similar mechanisms of resistance (eg, KRAS mutation). …

… ) EGFR TKI treatment is more potent than standard strategy (Liu et al. 2019). The hypofractionated
EGFR TKI … This result provides evidence of proper combination of EGFR TKIs and …

… Our results revealed a novel resistance mechanism of EGFR extracellular domain mutation.
In … heterogeneity in EGFR mutant NSCLC cases with acquired resistance to EGFR-TKIs. …

… a common acquired resistance mechanism to EGFR TKIs beyond EGFR mutations per se, …
a common mechanism mediating EGFR TKIs acquired resistance beyond EGFR mutations …

… The primary objective of the study was to characterize mechanisms of acquired resistance
to EGFR-TKI therapy. Biopsies were obtained in the least invasive manner possible and …

… Although some studies have examined the mechanisms and frequency of EGFR-TKI resistance…
The aim of this study was to analyze the mechanisms of acquired resistance to EGFR-TKI …

… found in EGFR-mutant NSCLC patients, acquired resistance … on the mechanism of acquired
resistance to EGFR-TKIs in … (EGFR) activating mutation, EGFR tyrosine kinase inhibitors (…

… EGFR mutant NSCLCs can develop resistance to EGFR TKIs, it is first critical to understand
the normal signaling mechanisms … of EGFR activity, it will become resistant to EGFR TKIs. …